Evidence map›Paper›PMID 40370503›Full record

ArticleEuropean heart journal open2025

Aspirin does not modify cardiovascular event risk in endometriosis in the California Teachers Study.

Alison Seitz, Cenai Zhang, Leslie Bull, Hooman Kamel, Halina White, Babak B Navi, Ja Hyun Shin, Jill Berkin, Jed H Kaiser, Vanessa Liao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alison SeitzDepartment of Neurology, University of Washington, Harborview Medical Center, 325 9th Ave, Box #359775, Seattle, WA 98104, USA.ORCID https://orcid.org/0000-0002-7451-4608
Cenai ZhangClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr 607, New York, NY 10021, USA.ORCID https://orcid.org/0000-0001-8137-1644
Leslie BullUniversity of California Los Angeles David Geffen School of Medicine, 885 Tiverton Dr., Los Angeles, CA 90095, USA.
Hooman KamelClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr 607, New York, NY 10021, USA.ORCID https://orcid.org/0000-0002-5745-0307
Halina WhiteClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr 607, New York, NY 10021, USA.ORCID https://orcid.org/0009-0001-6872-3403
Babak B NaviClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr 607, New York, NY 10021, USA.ORCID https://orcid.org/0000-0001-8424-6128
Ja Hyun ShinDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, 525 East 68th Street, Suite J-130, New York, NY 10065, USA.ORCID https://orcid.org/0000-0003-0652-5636
Jill BerkinDepartment of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai Hospital, 5 E 98th St 2nd Fl, New York, NY 10029, USA.ORCID https://orcid.org/0000-0003-3545-5198
Jed H KaiserClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr 607, New York, NY 10021, USA.ORCID https://orcid.org/0000-0003-4955-8606
Vanessa LiaoClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr 607, New York, NY 10021, USA.
Ava L LibermanClinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr 607, New York, NY 10021, USA.ORCID https://orcid.org/0000-0003-0184-6035

Funding

MOLECULAR GENETICS OF ZEBRAFISH PIGMENT CELL DEVELOPMENTF32NS010764 · NINDS · UNIVERSITY OF WASHINGTON · PI LISTER, JAMES A · 1998 to 2001
$73k
NINDS NIH HHS F32 NS010764
6 · The paper itself

Abstract

Aims: Endometriosis frequently affects reproductive aged females and is associated with increased cardiovascular disease risk. The aims of this study were (i) to confirm the relationship between cardiovascular disease and endometriosis and (ii) to test whether aspirin modified the effect of endometriosis on cardiovascular disease risk. Methods and results: A longitudinal cohort study was conducted using data from the California Teachers Study from enrolment (1995-1996) through the current administrative end follow-up (31 December 2020). Primary outcome was any incident major adverse cardiovascular event (MACE) defined using validated ICD-9/ICD-10 codes for stroke, myocardial infarction, and coronary heart disease. Inverse probability (IP) weights were used to estimate the causal effect of self-reported endometriosis on cardiovascular events. Of the included 120 435 participants, 13 754 (11.4%) reported history of endometriosis. There were 2159 admissions for MACE in the endometriosis group vs. 16 632 in the non-endometriosis group. After controlling for demographics and vascular comorbidities, risk of MACE was higher in the endometriosis group than in the non-endometriosis group [IP-weighted hazard ratio (HR) 1.10, confidence interval (CI) 1.04-1.15], particularly in participants < 40 years of age (IP-weighted HR 1.48, CI 1.08-2.02). Aspirin use did not modify the effect of endometriosis on MACE ( Conclusion: In a large American cohort, endometriosis was associated with increased risk of adverse cardiovascular events, especially in younger participants. Aspirin did not modify this risk. Research to determine how to best reduce cardiovascular risk in endometriosis is warranted.

Indexed as

Cardiovascular diseaseEndometriosisHeart diseaseMyocardial infarctionStroke

Identifiers

PMID40370503
PMCPMC12076410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.