ArticleProceedings of SPIE--the International Society for Optical Engineering2025
A 4D atlas of diffusion-informed spatial smoothing windows for BOLD signal in white matter.
Adam M Saunders, Gaurav Rudravaram, Nancy R Newlin, Michael E Kim, John C Gore, Bennett A Landman, Yurui Gao
Abstract read
In one paragraphArticle in Proceedings of SPIE--the International Society for Optical Engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Adam M SaundersDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Gaurav RudravaramDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Nancy R NewlinDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Michael E KimDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
John C GoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Bennett A LandmanDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Yurui GaoVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MMapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7MTRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7MOverall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3MControlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1MThe General Factor of Psychopathology in Psychosis and Severe Mental IllnessR01MH118273 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HECKERS, STEPHAN, WOODWARD, NEIL D. · 2019 to 2023
$4.5MBiophysical basis of functional MRI of white matterR01NS113832 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2020 to 2024
$2.4MEvaluating Advanced Diffusion of the Human Spinal Cord: Application to MSR01NS117816 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SMITH, SETH A · 2021 to 2025
$1.8MSecondary analysis of functional MRI and resting state connectivity in white matterRF1MH123201 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C, LANDMAN, BENNETT A. · 2021 to 2021
$1.3MInfluence of Sensory and Motor Dysfunctions on White - Gray Matters Functional Connectome in Preclinical ADR21AG083915 · NIA · VANDERBILT UNIVERSITY · PI GAO, YURUI · 2024 to 2024
$438kNCATS NIH HHS UL1 TR002243NIA NIH HHS R21 AG083915NIBIB NIH HHS P41 EB027061NIBIB NIH HHS R01 EB017230NICHD NIH HHS P50 HD103537NIMH NIH HHS R01 MH118273NIMH NIH HHS RF1 MH123201NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS113832NINDS NIH HHS R01 NS117816
6 · The paper itselfAbstract
Typical methods for preprocessing functional magnetic resonance images (fMRI) involve applying isotropic Gaussian smoothing windows to denoise blood oxygenation level-dependent (BOLD) signals, a process which spatially smooths white matter signals that occur along anisotropically-oriented fibers. Abramian et al. have proposed diffusion-informed spatial smoothing (DSS) filters to smooth white matter in a physiologically-informed manner. However, these filters rely on paired diffusion MRI and fMRI data, which are not always available. Here, we create DSS windows for smoothing fMRI data in the white matter based on the Human Connectome Project Young Adult population-averaged atlas of fiber orientation distribution functions. We smooth fMRI data from 63 subjects using the atlas-based DSS windows and compare the results with fMRI data smoothed with isotropic Gaussian windows at 1.04 mm full-width half-max (FWHM) and 3 mm FWHM. Compared to isotropic Gaussian windows, the atlas-based DSS windows result in fMRI data with a significantly higher local functional connectivity measured with regional homogeneity (ReHo,
Indexed as
atlasdiffusion-informed spatial smoothingdiffusion magnetic resonance imagingfunctional magnetic resonance imaginggraph signal processingwhite matter BOLD
Identifiers
PMID40370411
PMCPMC12074659
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