Evidence map›Paper›PMID 40370403›Full record

ArticleFrontiers in cellular and infection microbiology2025

A decade of genomic and phenotypic adaptation of carbapenem-resistant

Astri D Tagueha, Cartesio D'Agostini, Daniela Scribano, Carlotta Fiorilla, Dolores Limongi, Silvia Fillo, Luca Corrent, Martina Lipari, Florigio Lista, Lucia Nencioni and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Redefining Antimicrobial Resistance inInternational journal of molecular sciences · 2026
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Astri D Tagueha *Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Cartesio D'Agostini *Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Daniela ScribanoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Carlotta FiorillaLaboratory of Clinical Microbiology, Policlinico Tor Vergata, Rome, Italy.
Dolores LimongiDepartment of Promotion of Human Sciences and Quality of Life, San Raffaele Open University, Rome, Italy.
Silvia FilloScientific Department, Army Medical Center, Defense Institute for Biomedical Sciences, Rome, Italy.
Luca CorrentScientific Department, Army Medical Center, Defense Institute for Biomedical Sciences, Rome, Italy.
Martina LipariScientific Department, Army Medical Center, Defense Institute for Biomedical Sciences, Rome, Italy.
Florigio ListaScientific Department, Army Medical Center, Defense Institute for Biomedical Sciences, Rome, Italy.
Lucia NencioniDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Institute Pasteur Italia-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
Anna Teresa PalamaraDepartment of Public Health and Infectious Diseases, Laboratory Affiliated to Institute Pasteur Italia-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
Cecilia AmbrosiDepartment of Promotion of Human Sciences and Quality of Life, San Raffaele Open University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Thirty clinical isolates collected from two distinct time periods, defined as older (2010-2013), and recent (2022-2023),- were compared phenotypically (antibiotic resistance, growth, biofilm formation, desiccation tolerance, invasiveness) and genotypically (whole-genome sequencing). Results: All isolates displayed an extensively drug-resistant phenotype. Overall, respiratory isolates harbored a higher content of antibiotic-resistant genes (ARGs), with older isolates showing 12.5% increases in the average number of ARGs compared to recent urine isolates ( Conclusion: Significant genetic variability was found between past and recent isolates. Older isolates had more genes involved in adhesion and nutrient uptake, while recent respiratory strains demonstrated increased biofilm formation and invasiveness, reflecting adaptation to clinical pressures. These findings highlight the dynamic evolution of

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAdaptation, PhysiologicalAnti-Bacterial AgentsCarbapenemsBiofilmsDrug Resistance, Multiple, BacterialGenome, BacterialGenomicsGenotypeHumansMicrobial Sensitivity TestsPhenotypeVirulenceVirulence FactorsWhole Genome SequencingAnti-Bacterial AgentsCarbapenemsVirulence FactorsAcinetobacter baumanniibiofilmdesiccationhost-pathogen interactionmotilityphenotypic and genotypic comparison

Identifiers

PMID40370403
PMCPMC12075148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.