ArticleFrontiers in psychology2025
Atmospheric carbon monoxide and hospitalization for mental and behavioral disorders: insights from a longitudinal study in Shijiazhuang.
Article in Frontiers in psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Background and aim: Carbon monoxide (CO), a prevalent environmental pollutant, has been implicated in adverse mental health outcomes, but the mechanistic relationship between atmospheric CO levels and hospital admissions for mental and behavioral disorders remains unclear. This study investigates the epidemiological link between atmospheric CO and hospitalizations for mental health conditions in Shijiazhuang, China. Methodology: Clinical data from patients hospitalized with mental and behavioral disorders at The First Hospital of Hebei Medical University between January 2014 and December 2020 were analyzed. Daily atmospheric CO levels, temperature, and relative humidity were concurrently monitored. A generalized additive model (GAM) was used to explore the correlation between CO levels and hospital admissions. Blood samples from patients with depressive disorders were analyzed for MAPK3 expression, and a mouse model of CO-induced depression was employed to further explore the molecular mechanisms. Results: A total of 15,890 hospitalization records were included. A significant positive correlation was identified between CO levels and the number of daily hospitalizations, with the strongest effects observed when CO concentrations exceeded 40 μg/m Conclusion: This study provides compelling evidence for a significant association between atmospheric CO and hospitalizations for mental and behavioral disorders. The findings suggest that CO exposure may exacerbate mental health conditions, particularly in vulnerable populations. These insights underline the importance of air quality management and highlight potential pathways for therapeutic interventions targeting CO-induced mental health disorders.
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