Evidence map›Paper›PMID 40370203›Full record

ReviewMolecular nutrition & food research2025

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular-Related Complications.

María Ángeles Ávila-Gálvez, Antonio Vico-Padilla, Claus Schneider, Juan Carlos Espín, Antonio González-Sarrías, Juan Antonio Giménez-Bastida

Abstract readReview
In one paragraph

Review in Molecular nutrition & food research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Solvent-Guided Fractionation of GreenPlants (Basel, Switzerland) · 2026
    Article
  2. Review
  3. MicroencapsulatedFrontiers in veterinary science · 2026
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María Ángeles Ávila-GálvezLaboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain.
Antonio Vico-PadillaLaboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain.
Claus SchneiderDivision of Clinical Pharmacology, Department of Pharmacology, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-4215-967X
Juan Carlos EspínLaboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain.ORCID 0000-0002-1068-8692
Antonio González-SarríasLaboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain.ORCID 0000-0002-3407-0678
Juan Antonio Giménez-BastidaLaboratory of Food and Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS-CSIC, Murcia, Spain.ORCID 0000-0002-1244-8764

Funding

Novel pathways in eicosanoid biosynthesis and metabolismR35GM144091 · NIGMS · VANDERBILT UNIVERSITY · PI Claus Schneider · 2022 to 2026
$2.4M
Fundación Séneca 22030/PI/22Ministerio de Ciencia, Innovación y Universidades CNS2022-135253Ministerio de Ciencia, Innovación y Universidades PID2022-136419OB-I00Ministerio de Ciencia, Innovación y Universidades PID2022-136915NA-I00Ministerio de Ciencia, Innovación y Universidades PRTR-C17.I1Ministerio de Ciencia, Innovación y Universidades RyC2021-032111-INIGMS NIH HHS R35 GM144091NIGMS NIH HHS R35GM144091
6 · The paper itself

Abstract

Targeting angiogenesis as a strategy for treating cancer or vascular-associated complications is an inspiring field for many investigators. An active area within this discipline is the search for agents capable of modulating angiogenesis in order to ameliorate its structural and functional abnormalities associated with these diseases. (Poly)phenols are a broad group of molecules, many of which fall within the category of natural compounds with therapeutic potential. These potential medicinal effects have launched a considerable number of studies investigating the pro- and(or) anti-angiogenic properties of (poly)phenols in different (patho)physiological settings. The purpose of this review is to summarize the current evidence of the role of (poly)phenols in modulating angiogenesis. This review will guide the reader through preclinical and human investigations describing the pro- and anti-angiogenic effects of these compounds in different pathophysiological context, the cellular and molecular mechanisms associated, the key points in the design and evaluation of the effects described, and suggest new approaches to be considered in future studies to overcome the current limitations.

Indexed as

Angiogenesis InhibitorsNeoplasmsNeovascularization, PathologicPolyphenolsAngiogenesisAnimalsHumansAngiogenesis InhibitorsPolyphenolscancercardiovasculardiabetesendothelial cellsinflammation

Identifiers

PMID40370203
PMCPMC12319488

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.