Evidence map›Paper›PMID 40370118›Full record

ArticleHead & neck2025

Postdiagnosis Smoking Cessation and Survival Outcomes of Head and Neck Cancer Patients.

Elham Mohebbi, Garret Guthrie, Siddhi Patil, William Benjamin, Ming Tan, Jonathan P Giurintano, Matthew E Witek, Peter H Ahn, Kathryn Taylor, Gregory Wolf and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elham MohebbiDepartment of Oncology, School of Medicine, Georgetown University, Washington, District of Columbia, USA.ORCID 0000-0003-0868-4067
Garret GuthrieDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Washington, District of Columbia, USA.
Siddhi PatilDepartment of Oncology, School of Medicine, Georgetown University, Washington, District of Columbia, USA.
William BenjaminDepartment of Otolaryngology, Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
Ming TanDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Washington, District of Columbia, USA.
Jonathan P GiurintanoDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Matthew E WitekDepartment of Radiation Medicine, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.
Peter H AhnDepartment of Radiation Medicine, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.
Kathryn TaylorDepartment of Oncology, School of Medicine, Georgetown University, Washington, District of Columbia, USA.
Gregory WolfDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Ruzong FanDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Washington, District of Columbia, USA.
Laura S RozekDepartment of Oncology, School of Medicine, Georgetown University, Washington, District of Columbia, USA.

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOR, JACQUES EDUARDO · 2002 to 2013
$25.3M
NCI NIH HHS P30 CA051008NCI NIH HHS P50 CA097248NIH/NCI 2P50CA097248-06A1
6 · The paper itself

Abstract

backgroundPost-diagnosis smoking remains prevalent among head and neck squamous cell carcinoma (HNSCC) patients. Smoking cessation may improve patient outcomes.

methodsA prospective longitudinal cohort study (2008-2014) included 835 newly diagnosed HNSCC patients and followed up for 7 years. Participants were categorized by smoking behavior (never smokers, former smokers, quitters, continuing smokers, and intermittent smokers). The primary outcomes were overall survival (OS) and recurrence-free survival (RFS).

resultsSmoking cessation after diagnosis was associated with significantly improved OS. Quitters had a 61% reduction in mortality risk compared to continuing smokers (HR: 0.39, 95% CI: 0.22, 0.69), with the greatest benefit in oral cavity cancer patients (HR: 0.28, 95% CI: 0.12, 0.65). Intermittent smokers also showed improved survival (HR: 0.50, 95% CI: 0.31, 0.79). RFS did not significantly differ based on smoking behavior.

conclusionsSmoking cessation post-diagnosis improves OS, particularly in oral cavity cancer patients, highlighting the importance of targeted smoking cessation interventions in HNSCC care.

Indexed as

Head and Neck NeoplasmsSmoking CessationSquamous Cell Carcinoma of Head and NeckAdultAgedDisease-Free SurvivalFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesSmokingSurvival Analysishead and neck neoplasmsmouth neoplasmsrecurrencesmoking cessationsurvival analysis

Identifiers

PMID40370118
PMCPMC12434553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.