Evidence map›Paper›PMID 40369891›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial.

James Russell Pike, Alison R Huang, Nicholas S Reed, Michelle Arnold, Theresa Chisolm, David Couper, Jennifer A Deal, Nancy W Glynn, Adele M Goman, Kathleen M Hayden and 8 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03243422 (Aging and Cognitive Health Evaluation in Elders), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03243422 nacompletednot on this map

Aging and Cognitive Health Evaluation in Elders (ACHIEVE) Randomized Trial

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2018 to 2023Enrolled977ConditionsAging, Cognitive DeclineArmsSuccessful aging health education intervention, Hearing intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Article
  3. Connecting Beyond Words-Lessons From a Deaf Patient With Dementia.Journal of the American Geriatrics Society · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

James Russell PikeOptimal Aging Institute, New York University Grossman School of Medicine, New York, New York, USA.ORCID 0000-0002-6858-620X
Alison R HuangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Nicholas S ReedOptimal Aging Institute, New York University Grossman School of Medicine, New York, New York, USA.
Michelle ArnoldDepartment of Communication Sciences & Disorders, College of Behavioral & Community Sciences, University of South Florida, Tampa, Florida, USA.
Theresa ChisolmDepartment of Communication Sciences & Disorders, College of Behavioral & Community Sciences, University of South Florida, Tampa, Florida, USA.
David CouperDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Jennifer A DealDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Nancy W GlynnDepartment of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Adele M GomanSchool of Health and Social Care, Edinburgh Napier University, Edinburgh, UK.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Christine M MitchellDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Victoria SanchezDepartment of Otolaryngology-Head & Neck Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Kevin J SullivanThe MIND Center, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Nasya S TanDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Josef CoreshOptimal Aging Institute, New York University Grossman School of Medicine, New York, New York, USA.
Frank R LinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
ACHIEVE Collaborative Research Group

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
Aging, Cognition, and Hearing Evaluation in Elders (ACHIEVE) Randomized TrialR01AG055426 · NIA · JOHNS HOPKINS UNIVERSITY · PI CORESH, JOSEF, LIN, FRANK R · 2017 to 2021
$16.6M
National Institute of Deafness and Other Communication Disorders U01HL096812National Institute of Deafness and Other Communication Disorders U01HL096814National Institute of Deafness and Other Communication Disorders U01HL096899National Institute of Deafness and Other Communication Disorders U01HL096902National Institute of Deafness and Other Communication Disorders U01HL096917Neurocognitive data were collected using U.S. National Institutes of Health grantsNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS U01 HL096812NIA NIH HHS NIANIA NIH HHS R01 AG055426NIA NIH HHS R01AG055426NINDS NIH HHS
6 · The paper itself

Abstract

introductionResults from the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial suggest hearing intervention may not reduce 3-year cognitive decline in all older adults with hearing loss but may be beneficial in certain groups. This secondary analysis investigated if participants with multiple risk factors for cognitive decline received greater benefits.

methodsWe used a sample of dementia-free participants (N = 2692) from the Atherosclerosis Risk in Communities (ARIC) cohort to develop a predictive model for cognitive decline. The model was applied to baseline measures of ACHIEVE participants (N = 977) to estimate predicted risk. We tested an interaction between predicted risk and randomization to hearing intervention or health education control.

resultsAmong ACHIEVE participants in the top quartile of predicted risk, 3-year cognitive decline in the hearing intervention was 61.6% (95% confidence interval [CI]: 33.7%-94.1%) slower than the control. DISCUSSION: The effect of hearing intervention on reducing 3-year cognitive decline was greatest among individuals with multiple baseline risk factors associated with faster cognitive decline.

trial registrationClinicalTrials.gov Identifier: NCT03243422 HIGHLIGHTS: The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial tested the effect of hearing intervention on cognitive decline. Participants were recruited from the Atherosclerosis Risk in Communities (ARIC) cohort or de novo from the local community. A 48% reduction in cognitive decline was observed in ARIC cohort participants. In this secondary analysis, there was an interaction between hearing intervention and predicted risk of cognitive decline. Among participants in the top quartile of predicted risk of cognitive decline, hearing intervention slowed cognitive decline by 62%.

Indexed as

CognitionCognitive DysfunctionHearing LossAgedAged, 80 and overAgingFemaleHumansMaleRisk Factorsagingcognitioncognitive declinedementiahearinghearing aidshearing lossmemorypresbycusisrandomized control trial

Identifiers

PMID40369891
PMCPMC12078761

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.