Trial reportMedical science monitor : international medical journal of experimental and clinical research2025
Effects of Remifentanil and Dexmedetomidine with Propofol on Laryngeal Mask Airway Insertion, Hemodynamic Stability, and Pharyngolaryngeal Morbidity: A Prospective Study of 80 Patients.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Low-dose mivacurium facilitates laryngeal mask airway insertion in patients undergoing hysteroscopic surgery: a prospective, single-center, double-blind randomized controlled trial.Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Propofol is the most commonly used hypnotic for laryngeal mask airway (LMA) insertion but requires high doses when used alone, potentially causing cardiorespiratory depression. Muscle relaxants are recommended, yet no study has assessed the effects of remifentanil and dexmedetomidine before propofol induction on LMA insertion conditions. This prospective study aimed to compare the outcomes of propofol administered with remifentanil versus dexmedetomidine during short-duration operations requiring LMA placement. MATERIAL AND METHODS Eighty premedicated ASA I-II patients (age 18-65 years) were randomized to receive dexmedetomidine (Group D=40) or remifentanil (Group R=40) before propofol induction. Group D received a 10-minute infusion (1 μg.kg), while Group R received remifentanil (2 μg.kg) over 60 seconds. Baseline systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP), heart rate (HR), and bispectral index (BIS) values were recorded before induction and at intervals up to 5 minutes after LMA placement. RESULTS Group R had significantly shorter eyelash reflex loss and LMA insertion times, but longer apnea duration. Ideal LMA insertion conditions, full chin opening, and no movement were more frequent in Group R (p<0.05). In Group D, HR was significantly lower than in Group R 1 minute before and after LMA insertion, but significantly higher in the 4th and 5th minutes after insertion (p<0.05). MAP in Group R was significantly lower than in Group D at 1 minute before and all times after LMA insertion (p<0.05). CONCLUSIONS Administration of 2 μg/kg remifentanil before 2.5 mg/kg propofol induction resulted in better hemodynamics, faster LMA insertion, and higher rates of optimal conditions compared to 1 μg/kg dexmedetomidine.
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