Evidence map›Paper›PMID 40369757›Full record

ArticleAnimal bioscience2025

Effects of dietary 25-hydroxycholecalciferol supplementation on growth performance, blood vitamin D and antioxidant status in nursery pigs.

Chan Ho Kwon, Eva S Safaie, Savannah L Locke, Jannell A Torres, Zhaohui Yang, Xi Chen, Young Dal Jang

Abstract read
In one paragraph

Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Redox Homeostasis in Poultry/Animal Production.Antioxidants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chan Ho KwonDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, USA.
Eva S SafaieDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, USA.
Savannah L LockeDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, USA.
Jannell A TorresDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, USA.
Zhaohui YangNutribins LLC, Covina, CA, USA.
Xi ChenNutribins LLC, Covina, CA, USA.
Young Dal JangDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, USA.

Funding

U.S. Department of Agriculture's National Institute of Food and Agriculture and the Georgia Research Foundation 7007665
6 · The paper itself

Abstract

objectiveThis study was conducted to evaluate the effect of dietary 25-hydroxycholecalciferol (25-OHD3) supplementation on growth performance, blood 25-OHD3 level, and antioxidant parameters in nursery pigs.

methodsA total of 48 newly weaned piglets (5.27±1.42 kg initial body weight) were allotted to 3 treatments in 4 replicates with 4 pigs per pen for a 28-d feeding trial in two phases for d 0-14 (Phase 1) and d 14-28 (Phase 2) postweaning with basal diets without supplemental vitamin D3 (VD3). Treatments were: 1) basal diet+2,000 IU/kg VD3 supplementation, 2) basal diet+1,000 IU/kg 25-OHD3 supplementation, and 3) basal diet+2,000 IU/kg 25-OHD3 supplementation. Growth performance, plasma 25-OHD3 and malondialdehyde (MDA) levels, total antioxidant capacity, and superoxide dismutase activity were measured.

resultsThere was no significant difference in growth performance among dietary treatments until d 21 postweaning. Dietary 25-OHD3 supplementation increased feed intake (p<0.07) and growth rate (p<0.05) greater than the VD3 treatment in d 21-28 and d 14-28 postweaning, resulting in a greater growth rate in the overall period (p = 0.10). Increasing levels of 25-OHD3 supplementation resulted in greater plasma 25-OHD3 concentrations at d 14 and 28 postweaning (p<0.05), while decreasing plasma MDA levels at d 28 postweaning (p<0.05) with no differences in plasma superoxide dismutase activity and total antioxidant capacity. In the broken-line analysis, the estimated plasma 25-OHD3 concentration for plasma MDA concentration to reach the minimum level was 23.7 ng/mL (p<0.05).

conclusionSupplementing 25-OHD3 in nursery diets increased blood vitamin D status and had potential to enhance feed intake and growth rate in the late nursery period, while reducing oxidative stress compared with VD3 supplementation.

Indexed as

25-HydroxycholecalciferolAntioxidant StatusGrowth PerformanceNursery PeriodVitamin D3Weaning Pigs

Identifiers

PMID40369757
PMCPMC12415447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.