Evidence map›Paper›PMID 40369750›Full record

ArticleAnimal bioscience2025

Effect of inhibiting prolactin secretion on secondary hair follicle development in cashmere goats.

Chunhui Duan, Xuejiao Yin, Kexing Hao, Lechao Zhang, Yuchun Xie, Xueru Li, Yueqin Liu, Yingjie Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chunhui DuanCollege of Animal Science and Technology, Hebei Agricultural University, Baoding, China.
Xuejiao YinCollege of Animal Science and Technology, Hebei Agricultural University, Baoding, China.
Kexing HaoCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Lechao ZhangCollege of Animal Science and Technology, Hebei Agricultural University, Baoding, China.
Yuchun XieCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Xueru LiCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, China.
Yueqin LiuCollege of Animal Science and Technology, Hebei Agricultural University, Baoding, China.
Yingjie ZhangCollege of Animal Science and Technology, Hebei Agricultural University, Baoding, China.

Funding

Biological Breeding-Major Projects 2023ZD0405102China Agriculture Research System CARS-39Hebei Normal University 2025YB010Hebei Normal University 2025YB011
6 · The paper itself

Abstract

objectiveThis study aims to investigate the molecular mechanisms by which inhibiting prolactin (PRL) secretion affects secondary hair follicle (SHF) development in cashmere goats.

methodsA total of 20 cashmere goats were randomly assigned to either a bromocriptine (PRL inhibitor, BCT, 0.06 mg/kg BW) treatment (BCT+) or a control (BCT-) group. Blood and skin samples were collected monthly during telogen, and cashmere samples were collected after grow. Furthermore, the dermal papilla cells (DPCs) were isolated from SHF and cultured with PRL.

resultsThe results showed that the percentage of active SHF in telogen decreased (p<0.05) in the BCT+ group. The inhibition of PRL secretion reduced (p<0.05) the serum PRL concentration, and the expression of the PRL, SPRLR, Kit, and Fos genes. Transcriptome analysis of skin tissues identified differentially expressed genes. The results of the in vitro experiment indicated that 150 ng/mL PRL promoted (p<0.05) the proliferation and migration of DPCs.

conclusionThe Kit gene mediates PRL's regulation of SHF activation by stimulating the activation of Fos. These findings demonstrate that inhibiting PRL secretion in telogen can reduce the number of activated SHFs and width of hair bulbs.

Indexed as

FosGoatHair FollicleHair Papilla CellsKitProlactin

Identifiers

PMID40369750
PMCPMC12580954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.