Evidence map›Paper›PMID 40369720›Full record

ReviewInternational journal of dermatology2025

The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment.

Frank Jing, Ani Pazhava, Catherine Shachaf, Alexander Meves

Abstract readReview
In one paragraph

Review in International journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frank JingDepartment of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-0654-9163
Ani PazhavaDepartment of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0009-0003-8764-1731
Catherine ShachafOrlucent Inc., Los Gatos, California, USA.ORCID https://orcid.org/0000-0002-8178-5166
Alexander MevesDepartment of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-7462-8288

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules. Stromal cells regulate integrin signaling and are involved in remodeling the tumor microenvironment, driving critical processes such as cell migration, survival, angiogenesis, and proliferation. Advances in understanding the STE are creating new opportunities for early cancer detection and treatment. Innovations in molecular imaging, particularly for melanoma, are transforming cancer diagnostics by providing deeper insights into tumor biology, cellular interactions, and angiogenesis, paving the way for more personalized and timely therapeutic interventions. Among these advancements, in vivo skin fluorescent imaging (SFI) stands out as a powerful tool, offering real-time molecular insights at the point of care with the ability to improve patient management.

Indexed as

MelanomaSkin NeoplasmsStromal CellsTumor MicroenvironmentEarly Detection of CancerExtracellular MatrixHumansNeovascularization, PathologicOptical ImagingSkinin vivo imagingmelanomanevusreviewstromatissue remodelingtumor microenvironmentαvβ3 integrin

Identifiers

PMID40369720
PMCPMC12508701

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.