Evidence map›Paper›PMID 40369667›Full record

ArticleHereditas2025

RNA-binding protein gene NOP58 exhibits crucial prognostic and therapeutic value in Ewing sarcoma.

Yannan Geng, Lu Yang, Rui Shao, Tiantong Xu, Lilong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yannan Geng *Department of the Sixth Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, No. 190 Jieyuan Road, Hongqiao District, Tianjin, 300121, China.
Lu Yang *The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
Rui ShaoDepartment of the Sixth Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, No. 190 Jieyuan Road, Hongqiao District, Tianjin, 300121, China.
Tiantong XuDepartment of the Sixth Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, No. 190 Jieyuan Road, Hongqiao District, Tianjin, 300121, China. xutiantong@umc.net.cn.
Lilong ZhangDepartment of the Sixth Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, No. 190 Jieyuan Road, Hongqiao District, Tianjin, 300121, China. piaoxuezll@126.com.

Funding

Foundation of Tianjin Union Medical Center 2021YJ009Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-064B
6 · The paper itself

Abstract

backgroundOur aim was to identify crucial RNA-binding proteins (RBP) genes associated with Ewing sarcoma (EwS) in order to provide valuable insights into its mechanisms of tumorigenesis and to enhance therapeutic intervention.

resultsDifferential gene expression analysis identified candidate genes. Next, hub genes were generated by the results of protein-protein interaction (PPI) network, and univariate COX regression analysis. CIBERSORT was applied to analyze immune landscape. Furthermore, both in vitro and in vivo experiments were conducted to investigate the function of NOP58 in EwS.

resultsA total of 179 RBP-related genes were significantly different in EwS tissues and normal controls. Among these, NOP58 ribonucleoprotein (NOP58) was considered as the hub gene, demonstrating significant prognostic value. Significantly, high NOP58 expression correlated with poor prognosis of EwS patients. Additionally, the levels of NOP58 were significantly up-regulated in EwS cells compared with human mesenchymal stem cells. Furthermore, knockdown of NOP58 notably inhibited the proliferation and migration of EwS cells. Moreover, NOP58 deficiency remarkably induced apoptosis and cell cycle arrest in EwS cells. In vivo studies on tumor-bearing mice demonstrated that NOP58 downregulation significantly inhibited tumor growth in EwS.

conclusionCollectively, downregulation of NOP58 could inhibit the proliferation and migration of EwS cells in vitro and reduce murine xenograft tumor growth in vivo. These findings identified NOP58 as a promising regulator of EwS tumorigenesis, suggesting it may serve as a potential therapeutic target for EwS treatment.

Indexed as

Bone NeoplasmsRNA-Binding ProteinsSarcoma, EwingAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMicePrognosisProtein Interaction MapsRNA-Binding ProteinsCell growthEwing sarcomaNOP58PrognosisRNA-binding protein

Identifiers

PMID40369667
PMCPMC12076867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.