ArticleEuropean journal of medical research2025
The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Robotic versus endoscopic breast-conserving surgery: a comparative analysis of clinical outcomes and aesthetic outcomes in breast cancer.Journal of robotic surgery · 2026Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesA critical measure to reduce the risk of ipsilateral breast tumor recurrence after breast-conserving surgery (BCS) for patients with early invasive breast cancer (BC) is ensuring negative margins through frozen section intraoperative margin assessment (FSIMA).This study aims to evaluate the influencing factors and prognosis associated with positive initial margins in FSIMA.
methodsThe clinical data of 436 BC patients treated with BCS were retrospectively analyzed, and long-term follow-up outcomes were evaluated.
resultsAmong the 436 patients, approximately 90.8% (396/436) underwent successful BCS, while 71.8% (313/436) exhibited initial negative margins based on FSIMA. A total of 123 patients (28.2%) had positive initial margins, following additional excisions in some cases, 89 patients achieved negative margins. Univariate and multivariate analyses revealed significant differences between the positive and negative margin groups in tumor diameter, distance from the tumor to the nipple, and axillary lymph node metastasis (P < 0.05). No significant differences were observed in disease-free survival or overall survival between the two groups (P > 0.05).
conclusionsThe findings suggest that tumor diameter, the distance between the tumor and nipple, and axillary lymph node metastasis may influence the determination of positive initial margins in FSIMA. Positive initial margins do not appear to influence disease-free survival (DFS) or overall survival (OS) among BC patients treated with BCS.
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