Evidence map›Paper›PMID 40369602›Full record

Trial reportEuropean journal of medical research2025

Reducing the length of hospital stay for patients undergoing primary total knee arthroplasty by application of enhanced recovery after surgery (ERAS) pathway: a multicenter, prospective, randomized controlled trial.

Chenxi Liao, Xingning Lai, Jie Zhong, Wencong Zeng, Jiannan Zhang, Wanxin Deng, Jiayun Shu, Haobo Zhong, Liangyu Cai, Ren Liao

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03517098 (Enhanced Recovery After Surgery), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03517098 nacompletednot on this map

Enhanced Recovery After Surgery (ERAS) Pathway for Primary Hip and Knee Arthroplasty: a Prospective, Controlled, Randomized Clinical Trial

TypeinterventionalSponsorWest China HospitalRan2021 to 2023Enrolled640ConditionsArthroplasty, Replacement, Hip, KneeArmsThe ERAS group, The non-ERAS group
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenxi Liao *Department of Anesthesia and Operation Center, Research Unit for Perioperative Stress Assessment and Clinical Decision, Chinese Academy of Medical Sciences (2018RU012), West China Hospital of Sichuan University, No.37 Guo Xue Lane, Chengdu, 610041, China.ORCID http://orcid.org/0009-0008-1865-1932
Xingning Lai *Department of Anesthesia and Operation Center, Research Unit for Perioperative Stress Assessment and Clinical Decision, Chinese Academy of Medical Sciences (2018RU012), West China Hospital of Sichuan University, No.37 Guo Xue Lane, Chengdu, 610041, China.ORCID http://orcid.org/0000-0001-9096-7474
Jie Zhong *Department of Anesthesia and Operation Center, Research Unit for Perioperative Stress Assessment and Clinical Decision, Chinese Academy of Medical Sciences (2018RU012), West China Hospital of Sichuan University, No.37 Guo Xue Lane, Chengdu, 610041, China.ORCID http://orcid.org/0009-0003-3735-0282
Wencong ZengDepartment of Anesthesiology, Huizhou First Hospital, No.20 Jiangbei Sanxin South Road, Huizhou, 516001, China.ORCID http://orcid.org/0009-0005-2536-9407
Jiannan ZhangDepartment of Anesthesiology, No. 8, Wuxi Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Zhongnan West Road, Wuxi, 214071, China.
Wanxin DengDepartment of Anesthesiology, The First People's Hospital of Longquanyi District, Chengdu, 610100, China.
Jiayun ShuDepartment of Anesthesiology, Xindu District People's Hospital of Chengdu, No.199 Yuying Road South Section, Chengdu, 610599, China.
Haobo ZhongDepartment of Orthopedics, Huizhou First Hospital, No.20 Jiangbei Sanxin South Road, Huizhou, 516001, China.ORCID http://orcid.org/0000-0003-0070-1934
Liangyu CaiDepartment of Anesthesiology, No. 8, Wuxi Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine, Zhongnan West Road, Wuxi, 214071, China.
Ren LiaoDepartment of Anesthesia and Operation Center, Research Unit for Perioperative Stress Assessment and Clinical Decision, Chinese Academy of Medical Sciences (2018RU012), West China Hospital of Sichuan University, No.37 Guo Xue Lane, Chengdu, 610041, China. liaoren7733@wchscu.cn.ORCID http://orcid.org/0000-0003-3963-4310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe proportion of elderly patients undergoing Total knee arthroplasty (TKA) is growing. Optimizing and accelerating postoperative recovery for TKA patients is critical in clinical practice. Enhanced Recovery After Surgery (ERAS) is a protocol involving a series of evidence-based perioperative optimization strategies to minimize surgical stress and expedite recovery, and a multidisciplinary ERAS pathway was established jointly by anesthesiologists and orthopedic surgeons in this study. The authors hypothesized that application of the ERAS pathway can reduce the length of hospital stay (LOS) for patients undergoing primary TKA. MATERIALS AND

methodsThis multicenter, prospective, randomized controlled trial was conducted from February 1, 2021 to January 31, 2023, and included patients undergoing elective primary TKA. 320 patients were randomly assigned to either the ERAS group (practice according to the ERAS pathway) or the control group (without ERAS pathway implementation) in a 1:1 ratio. The primary outcome was the total LOS in hospital.

resultsLOS in the ERAS group was 5.92 ± 1.16 days, significantly shorter than the 8.17 ± 1.76 days in the control group (p < 0.001). Postoperative LOS and time to independent ambulation were significantly shorter in the ERAS group compared to the control group (p < 0.001). On postoperative day 1, significantly less participants reported pain both in rest and during mobilization in the ERAS group than the control group (p < 0.001). The incidences of thirst and postoperative nausea and vomiting (PONV) was significantly reduced in the ERAS group compared to the control group (16.8% vs. 88.6%, and 2.6% vs. 24.7%, respectively, p < 0.001). No perioperative deaths or reoperations within 30 days occurred in either group.

conclusionThe application of an ERAS pathway for primary TKA significantly reduces LOS, alleviates postoperative pain, and lowers the incidence of adverse events compared to perioperative management without ERAS pathway implementation.

trial registrationThe National Institutes of Health Clinical Trials Registry, NCT03517098. Registered on April 24, 2018.

Indexed as

Arthroplasty, Replacement, KneeEnhanced Recovery After SurgeryLength of StayAgedFemaleHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesRecovery of FunctionEnhanced recovery after surgeryLength of hospital stayPrimary total knee arthroplasty

Identifiers

PMID40369602
PMCPMC12079852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.