Evidence map›Paper›PMID 40369586›Full record

Trial reportBMC health services research2025

Determinants of implementation of a stepped care intervention for adolescents and youth living with HIV in Kenya: a qualitative evaluation.

Nok Chhun, Dorothy I Mangale, Kawango Agot, Winnie A Owade, Julie Kadima, Jacinta Badia, James K Kibugi, Pamela K Kohler, Grace John-Stewart, Kristin Beima-Sofie

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC health services research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05007717 (Data-informed Stepped Care), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05007717 nacompletednot on this map

Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes (UH3)

TypeinterventionalSponsorUniversity of WashingtonRan2022 to 2023Enrolled1,911ConditionsAdolescent Behavior, HivArmsData-informed Stepped Care (DiSC)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nok ChhunDepartment of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA, 98195, USA. nchhun@uw.edu.
Dorothy I MangaleDepartment of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA, 98195, USA.
Kawango AgotImpact Research and Development Organization, Kisumu, Kenya.
Winnie A OwadeImpact Research and Development Organization, Kisumu, Kenya.
Julie KadimaImpact Research and Development Organization, Kisumu, Kenya.
Jacinta BadiaImpact Research and Development Organization, Kisumu, Kenya.
James K KibugiImpact Research and Development Organization, Kisumu, Kenya.
Pamela K KohlerDepartment of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA, 98195, USA.
Grace John-StewartDepartment of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA, 98195, USA.
Kristin Beima-SofieDepartment of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA, 98195, USA.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV OutcomesUH3HD096906 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2020 to 2022
$3.1M
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV OutcomesUG3HD096906 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2018 to 2019
$1.9M
Improving Retention in Care for Adolescents and Young Adults in Kenya: Implementation Science to Support Adaptation and Integration of a Stepped Care InterventionF31HD105513 · NICHD · UNIVERSITY OF WASHINGTON · PI CHHUN, NOK · 2022 to 2024
$115k
Eunice Kennedy Shriver National Institute of Child Health and Human Development UG3/UH3 HD096906NIAID NIH HHS P30 AI027757NICHD NIH HHS F31 HD105513NICHD NIH HHS UG3 HD096906NICHD NIH HHS UH3 HD096906
6 · The paper itself

Abstract

backgroundDifferentiation of HIV services, a client-centered strategy, may improve care outcomes among adolescents and youth living with HIV (AYLHIV). Understanding health provider perceptions of barriers and facilitators that influence implementation can optimize adoption and sustainment of health systems interventions.

methodsThe Data-informed Stepped Care (DiSC) study was a cluster randomized controlled trial of a stepped care intervention in 24 HIV care facilities in Kenya. At each visit, providers used an assessment tool to allocate AYLHIV to services according to level of need. Stable clients were allocated to differentiated service delivery (DSD) with less frequent visits. Intensified services, including behavioral counseling, were provided for those with greater likelihood of loss to follow-up, mental health issues, or viral non-suppression. We conducted focus group discussions (FGDs) with providers across 12 intervention sites between January-February 2023. FGDs used a semi-structured interview guide, grounded in the Consolidated Framework for Implementation Research, which were audio-recorded and transcribed. Transcripts were analyzed using a team-based rapid turnaround approach to characterize key determinants influencing adoption, reach, and fidelity.

resultsProviders were enthusiastic about, and quick to adopt, the DiSC intervention. They found the DiSC tool easy to use and felt it provided a relative advantage by improving service delivery efficiency and prioritizing time with higher need AYLHIV. Providers noted the importance of tool flexibility to align with changing national guidelines. They expressed concerns about compatibility with existing workflows at facilities exclusively using electronic medical record (EMR) systems, suggesting EMR integration will be needed for intervention sustainment. AYLHIV eligible for DSD benefited from clinic visit intervals that aligned with the school calendar, which posed a challenge for reaching AYLHIV in more intensive steps. Provider collective efficacy was important in consistent implementation of DiSC and was facilitated by continuous quality improvement meetings, access to knowledge and information, and perceived intervention effectiveness. Supportive leadership was an important driver of implementation success, through availing space for mental health counseling sessions and time for client-provider interactions outside standard operating hours.

conclusionsConsideration of alignment with national policy, integration into clinic workflows, school schedules, and leadership engagement, will be important for sustained use of differentiated care interventions.

trial registrationClinicalTrials.gov, NCT05007717. Registration date: July 13, 2021.

Indexed as

HIV InfectionsAdolescentAdultAttitude of Health PersonnelFemaleFocus GroupsHumansKenyaMaleQualitative ResearchYoung AdultAdolescents and young adultsConsolidated framework for implementation research (CFIR)Differentiated service deliveryHIVImplementation determinantsImplementation scienceKenya

Identifiers

PMID40369586
PMCPMC12079965

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.