ArticleBMC genomics2025
Negative effect of seasonal heat stress on testis morphology and transcriptomes in Angora rabbit.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Dietary Arginine Supplementation Mitigates Heat Stress-Induced Testicular Dysfunction Through Arginine-Related Metabolic Remodeling and Autophagy-Associated Stress Adaptation in a Rongchang Boar Model.Animals : an open access journal from MDPI · 2026Article
- Comparative Evaluation of Sexual Behavior, Semen Characteristics and Environmental Modulation in Local Algerian and New Zealand White Rabbit Bucks.Veterinary sciences · 2026Article
- Global Warming, Fertility, and Spermatogenesis Decline: Global and Regional Evidence from 195 Countries and Implications for Climate Adaptation Policy.International journal of environmental research and public health · 2026Article
- The effect of salubrinal on the endoplasmic reticulum stress pathway in heat-stressed spermatogonial cells in vitro.FEBS open bio · 2026Article
- Effects of shaving on reproductive performance and protein metabolism in bucks under heat stress conditions.Frontiers in veterinary science · 2026Article
- Environmental stress and stallion fertility: mechanistic insights, evidence gaps, and functional implications.Frontiers in veterinary science · 2026Review
- Environmental determinants of male infertility: emerging threats and technological interventions.Frontiers in medicine · 2026Review
- Intrauterine Growth-Restricted Pig-Associated Testicular Transcriptome Analysis Reveals microRNA-mRNA Regulatory Networks.Animals : an open access journal from MDPI · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe temperature of testes exposed to hyperthermic conditions can affect livestock reproductive performance. This study aimed to explore the difference in semen quality, testicular morphological structure, and gene expression profiles of testes of Angora rabbits in spring (no heat stress), summer (intense heat stress), and autumn (no heat stress) seasons.
resultsHeat stress during summer significantly reduced semen quality and damaged testicular morphology and spermatogenesis, which recovered to normal levels in autumn, although semen quality recovery was notably slow. RNA-Seq analysis showed that the expression levels of 8703 genes changed significantly in summer, but their expression levels in autumn returned to those in spring, which was consistent with the testicular morphology analysis results in different seasons. Enrichment analysis revealed that the DEGs were primarily associated with spermatogenesis, sperm motility, spermatid development, cell death, regulation of apoptotic processes, and responses to external stimuli. The MAPK, Rap1, TNF, Ras, Apoptosis, and Wnt signaling pathways regulated reproduction under heat stress. In addition, minimal variations in testicular morphology and gene expression profiles were observed between autumn and spring. Gene expression pattern analysis showed that genes with high expression in summer mainly participated in the regulation of cell apoptosis, immunity, and response to heat stress, whereas genes with low expression in summer mainly participated in the regulation of spermatogenesis.
conclusionsThis study investigated the influence of different seasons on the reproductive performance of male Angora rabbits and provided initial insights into the molecular regulatory mechanisms underlying the testicular response to heat stress during summer.
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