ArticleBMC pediatrics2025
Early detection of pulmonary vasculopathy in children with sickle cell disease by new echocardiography-based blood speckle technology.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Novel Insights from Blood Speckle Imaging for the Assessment of Left Ventricular Flow Dynamics in Adult Patients: A Three-Patient Proof-of-Concept Case Series in the Context of Current Evidence.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Postnatal Steroids in Preterm Infants: A Narrative Review Series-Part 2: Cardiovascular Impacts.Children (Basel, Switzerland) · 2026Review
- Echocardiographic and platelet markers of cardiovascular strain in sickle cell disease with superimposed preeclampsia: a perspective.Annals of medicine and surgery (2012) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRight ventricle (RV) dysfunction because of pulmonary vasculopathy is the most common cause of death in sickle cell disease (SCD). This study aimed to explore the diagnostic accuracy of blood-speckle tracking and vortex detection in the early detection of pulmonary vasculopathy in patients with SCD.
methodsThis study was conducted as a cross-sectional study including thirty patients and thirty controls. Patients with SCD were examined using 3D echocardiography to determine the presence of RV dysfunction, as a surrogate of pulmonary vasculopathy: in addition to blood speckle tracking echocardiography to determine the vortex timing in the RV and its presence or absence in the pulmonary artery. Patients' demographic and hematologic data were also retrieved from patients' files.
resultsPulmonary vortex formation was 100% sensitive in the detection of RV dysfunction. LDH (Lactate Dehydrogenase) was the only variable significantly different between cases with pulmonary vortex formation and those without (520 vs. 257, P < 0.001), LDH > 400 was 72% sensitive and 100% specific in the detection of pulmonary vortex formation.
conclusionsPulmonary vortex formation was a sensitive indicator of RV dysfunction, thus suggesting its accuracy in the early detection of early pulmonary vascular changes in SCD. LDH as a marker of intravascular hemolysis, is a sensitive marker that can be used for risk stratification of SCD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.