Impact of Mechanical Ventilation and Anesthesia on PET Tracer Kinetics for Combined PET/fMRI Studies in Rats.

Yan Ma, Laura Kuebler, Sabrina Haas, Andreas Maurer, Kristina Herfert

Abstract read

In one paragraph

Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan Ma *Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.

Laura Kuebler *Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.

Sabrina HaasWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.

Andreas MaurerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany.

Kristina HerfertWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Tuebingen, Germany. kristina.herfert@med.uni-tuebingen.de.ORCID http://orcid.org/0000-0003-0231-7717

Funding

Deutsche Forschungsgemeinschaft 530241490

6 · The paper itself

Abstract

purposePositron Emission Tomography (PET), a crucial tool in molecular brain imaging, has evolved into a hybrid system through integration with functional MRI (fMRI). This advancement facilitates the simultaneous recording of molecular and functional data in animal models, offering insights into neuroreceptor and neurotransmitter dynamics and their effects on brain function. While mechanical ventilation is often used in small animal fMRI to stabilize physiological blood gas levels, its effects on PET tracer kinetics remain underexplored. PROCEDURES: This study examines the kinetics of [

resultsResults indicate significant variations in tracer kinetics: increased peak levels, a shorter time to peak, and a faster tracer equilibrium in standard uptake value ratio were observed in spontaneously breathing animals versus those under mechanical ventilation. The anesthesia type also strongly influenced the tracer kinetics: α-chloralose anesthesia reduced brain uptake, whereas isoflurane led to a more rapid equilibrium.

conclusionsThese findings underscore the profound impact of mechanical ventilation and anesthesia selection on PET tracer kinetics in hybrid PET/fMRI studies. The study highlights that those protocols established for fMRI are not directly transferable to PET imaging in small animals, emphasizing the necessity for a careful investigation of the influence of anesthesia and ventilation techniques on tracer kinetics.

Indexed as

AnesthesiaMagnetic Resonance ImagingPositron-Emission TomographyRespiration, ArtificialAnimalsBrainKineticsMaleRacloprideRadioactive TracersRatsRats, Sprague-DawleyRacloprideRadioactive TracersAnesthesiaMechanical ventilationPositron emission tomographyTracer kinetics

Identifiers

PMID40369384

DOI10.1007/s11307-025-02006-3

PMCPMC12162802

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.