ArticlePediatric research2026
Risk factors for severe pertussis in children and the application of exchange transfusion.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influencing factors for severe pertussis among Chinese children: A meta-analysis.Human vaccines & immunotherapeutics · 2026Pooled it
- Early risk stratification for ICU admission in hospitalized children with pertussis: development and internal validation of an admission-time prediction model.BMC infectious diseases · 2026Article
- Severe Pertussis During Early Infancy from a High-Altitude Region: Two Clinical Cases and Literature Review.Journal of clinical medicine · 2026Article
- Factors associated with pertussis infection and suspected cases in the Aseer Region, Saudi Arabia: a retrospective cross-sectional analysis study.Frontiers in public health · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify risk factors for severe pertussis and assess the efficacy of exchange transfusion in children.
methodsWe analyzed pediatric pertussis cases, comparing mild and severe presentations using hospital data on demographics, symptoms, lab findings, echocardiography, and complications, and employed ROC analysis to determine severe pertussis risk factors.
resultsOur study analyzed 119 mild and 64 severe pertussis cases, with severe cases characterized by earlier onset, spasmodic cough, shortness of breath, and rales. Risk factors for severity included lack of DTaP vaccination and pulmonary hypertension. Severe cases also showed higher WBC and lymphocyte counts and more mixed infections. Logistic regression identified shortness of breath, no DTaP, younger age, and high WBC as severity predictors (P < 0.05). ROC analysis predicted severity with age < 3.68 months and WBC > 27.93 × 10
conclusionClinicians should closely monitor unvaccinated children with shortness of breath, onset before 3.68 months, and WBC > 27.93 × 10 IMPACT: This study delineates four key predictors of severe pertussis in children: younger age, lack of DTaP vaccination, shortness of breath, and elevated white blood cell (WBC) counts. We establish WBC > 27.93 × 10
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