Evidence map›Paper›PMID 40369170›Full record

ArticlePsychopharmacology2025

The serum levels of polyunsaturated fatty acids contribute to the antidepressant-like effects of 18β-Glycyrrhetinic acid in mice.

Wanzhao Ding, Maohua Yao, Xiaoling Liang, Winghei Wong, Wei Yao, Ji-Chun Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. 18β-Glycyrrhetinic Acid AttenuatesAnimals : an open access journal from MDPI · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanzhao DingDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Maohua YaoGuangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China.
Xiaoling LiangGuangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China.
Winghei WongDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Wei YaoGuangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, 510632, China.
Ji-Chun ZhangDepartment of Physiology, School of Medicine, Jinan University, Guangzhou, 510632, China. jczhang@jnu.edu.cn.

Funding

National Natural Science Foundation of China 82204786National Natural Science Foundation of China 82271563
6 · The paper itself

Abstract

rationale18β-Glycyrrhetinic acid (18β-GA) exhibits antidepressant-like effects in mice, but the underlying mechanisms remain unclear.

objectiveThis study aimed to explore the role of serum polyunsaturated fatty acids in the antidepressant-like effects of 18β-GA.

results18β-GA exerted antidepressant-like effects in mice susceptible to chronic social defeat stress (CSDS). These effects were associated with increased serum levels of docosahexaenoic acid (DHA), neuroprotectin D1 (NPD1), and N-docosahexaenoylethanolamide (DEA), alongside decreased levels of 14,15-dihydroxyeicosatrienoic acid (DHET). Additionally, 18β-GA restored the suppressed brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB) signaling pathway and reduced the elevated pro-inflammatory cytokine levels in CSDS-susceptible mice.

conclusionsThis study demonstrates that the antidepressant-like effects of 18β-GA in CSDS-susceptible mice are closely associated with DHA and its metabolites.

Indexed as

Antidepressive AgentsDepressionFatty Acids, UnsaturatedGlycyrrhetinic AcidAnimalsBehavior, AnimalBrain-Derived Neurotrophic FactorDisease Models, AnimalDocosahexaenoic AcidsMaleMiceMice, Inbred C57BLSocial DefeatStress, Psychological18alpha-glycyrrhetinic acidAntidepressive AgentsBrain-Derived Neurotrophic FactorDocosahexaenoic AcidsFatty Acids, UnsaturatedGlycyrrhetinic Acid18β-glycyrrhetinic acidAnti-inflammatoryBDNFPolyunsaturated fatty acidsTrkB

Identifiers

PMID40369170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.