Evidence map›Paper›PMID 40369112›Full record

ArticleScientific reports2025

Helicobacter pylori infection might be a protective factor against Parkinson's disease.

Xiao Xiao, Zuo Wang, Huiwang Zhang, Binghong Li, Qinchuan Hou, Jinxia Wang, Wenbo Xiu, Rui Zhang, Gao Zhang, Yongli Lan and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xiao XiaoClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Zuo WangClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Huiwang ZhangHealth Management Center & Health Management Research Institute, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Binghong LiHealth Management Center & Health Management Research Institute, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Qinchuan HouHealth Management Center & Health Management Research Institute, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Jinxia WangClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Wenbo XiuClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Rui ZhangHealth Management Center & Health Management Research Institute, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Gao ZhangClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Yongli LanHealth Management Center & Health Management Research Institute, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Yang ChenClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Mo ZhangHealth Management Center & Health Management Research Institute, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chaonan SunClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Yanping GaoClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
An LiClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Xiong ZhuDepartment of Prenatal Diagnosis, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Caiping GaoDepartment of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chong HeClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Fang LuClinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. lufangfang@126.com.
Ping ShuaiHealth Management Center & Health Management Research Institute, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. shuaiping@med.uestc.edu.cn.

Funding

National Natural Science Foundation of China 82450003Sichuan Science and Technology Programgrants 2023YFS0022
6 · The paper itself

Abstract

The gastrointestinal tract is not only an important component of the digestive system but also a crucial part of the body's immune system. Numerous studies have reported that gastrointestinal immunity plays a critical role in many extraintestinal diseases, including neurodegenerative disorders. However, the relationship between gastric mucosal immunity and neurodegenerative diseases, such as Parkinson's disease(PD), remains underexplored. The rate of H. pylori infection was assessed using the 13 C-Urea Breath Test (13 C-UBT) in a case-control study involving 315 PD patients and a control group of 22,383 outpatients. Multivariate regression and propensity score matching (PSM) analyses were employed to adjust for confounding factors. A lower H. pylori infection rate was found in PD cases compared to outpatient controls (DOB ≥ 8, 22.5% versus 27.5%, p = 0.049; DOB ≥ 4, 28.6% versus 33.9%, p = 0.046). After adjusting for confounding factors, the H. pylori infection rate remained lower in PD cases compared to controls. The study revealed an inverse correlation between H. pylori infection and PD, suggesting that H. pylori infection could potentially act as a protective factor against the development of PD.

Indexed as

Helicobacter InfectionsHelicobacter pyloriParkinson DiseaseAgedBreath TestsCase-Control StudiesFemaleHumansMaleMiddle AgedProtective FactorsGastrointestinal mucosal immuneH. pylori infectionParkinson’s disease

Identifiers

PMID40369112
PMCPMC12078797

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.