Evidence map›Paper›PMID 40369073›Full record

ArticleNature2025

Solid phase transitions as a solution to the genome folding paradox.

Joan Pulupa, Natalie G McArthur, Olga Stathi, Miao Wang, Marianna Zazhytska, Isabella D Pirozzolo, Ahana Nayar, Lawrence Shapiro, Stavros Lomvardas

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Redox-Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Joan Pulupa *Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Natalie G McArthur *Department of Biological Sciences, Columbia University, New York, NY, USA.
Olga StathiMortimer B. Zuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, NY, USA.
Miao WangDepartment of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Marianna ZazhytskaDepartment of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Isabella D PirozzoloMedical Scientist Training Program, Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0003-0025-8549
Ahana NayarBarnard College, New York, NY, USA.
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Stavros LomvardasDepartment of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, New York, NY, USA. sl682@cumc.columbia.edu.ORCID 0000-0002-7668-3026

Funding

Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Olfactory receptor mRNAs as lncRNAs that regulate genomic interactionsR01DC018744 · NIDCD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stavros Lomvardas · 2020 to 2026
$3.7M
Interrogating genome folding trajectories in health and diseaseU01DA052783 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOMVARDAS, STAVROS · 2020 to 2024
$3.1M
NIDA NIH HHS U01 DA052783NIDCD NIH HHS R01 DC018744NIGMS NIH HHS T32 GM145440
6 · The paper itself

Abstract

Ultra-long-range genomic contacts, which are key components of neuronal genome architecture

Indexed as

Biomolecular CondensatesEnhancer Elements, GeneticGenomeAnimalsDNADNA-Binding ProteinsLIM-Homeodomain ProteinsMiceNucleotide MotifsOlfactory Receptor NeuronsReceptors, OdorantTranscription FactorsTranscription, GeneticDNADNA-Binding ProteinsLIM-Homeodomain ProteinsReceptors, OdorantTranscription Factors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.