ArticleNature2025
Radiation-induced amphiregulin drives tumour metastasis.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Preliminary results from a phase II trial of spatially fractionated radiotherapy combined with immunotherapy and anti-angiogenic therapy in patients with bulky solid tumors: early evidence of promising efficacy and favorable safety.Radiation oncology (London, England) · 2026Trial
- Continuous Androgen Deprivation Therapy with or Without Metastasis-directed Therapy for Oligometastatic Prostate Cancer: The Multicenter Phase 2 Randomized EXTEND Trial.European urology · 2025Trial
- Unlocking the therapeutic potential of immuno-radiotherapy: insights from preclinical and clinical research.Oncoimmunology · 2026Review
- Addition of pulsed electric field ablation to SBRT for lung tumors: effect on health-related quality of life.Lung cancer management · 2026Article
- Molecular pathways linking the gut microbiome to antitumor immunity.Trends in microbiology · 2026Review
- Challenges and opportunities in combining radiotherapy and immunotherapy for localized pancreatic cancer.Nature reviews. Gastroenterology & hepatology · 2026Review
- Review
- Radiation-Triggered Chemokine-Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An Injectable Metal-Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post-Surgical Osteosarcoma Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting tumour-neuron synapses with intracavitary RNA delivery prevents glioblastoma recurrence.Nature biomedical engineering · 2026Article
- Review
- Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.The Journal of clinical investigation · 2026Review
- Revisiting the Abscopal Effect in the Era of Immuno-Radiotherapy: Mechanisms, Challenges, and Clinical Perspectives.Biomolecules · 2026Review
- Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies.Materials today. Bio · 2026Review
- Article
- Combinatorial Delivery of Low-Dose Radiotherapy and Immunotherapy to Patients with Immune-Excluded Tumors Enhances CD8+ T-cell Functionality.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- The microbiota-lymphocyte protective axis (MLPA): a novel paradigm for overcoming radiation-induced lymphopenia (RIL) and potentiating the efficacy of tumor immuno-combination therapy.Cancer immunology, immunotherapy : CII · 2026Review
- Radiotherapy-Associated Pain in Head and Neck Cancer: From Clinical Burden to Neuroimmune Modulator.Journal of clinical medicine · 2026Review
- Multidrug resistance in cancer: current understandings and future perspective.Molecular biomedicine · 2026Review
- Radiotherapy, EMP and dormancy in TME: An integrated perspective on tumor microenvironments and long-term relapse.iScience · 2026Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
23 authors.
András Piffkó *Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5300-6594
Kaiting Yang *Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9328-5655
Arpit Panda *Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Janna HeideDepartment of Obstetrics and Gynecology/Section Gynecologic Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-3528-1602
Krystyna TesakDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0002-8421-995X
Chuangyu WenDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
Katarzyna ZawieraczDepartment of Pathology, Section of Hematology/Oncology, University of Chicago, Chicago, IL, USA.
Liangliang WangDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8340-5190
Emile Z NaccashaDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0005-5445-9313
Jason BugnoDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
Yanbin FuDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
Dapeng ChenDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
Leonhard DonleDepartment of Obstetrics and Gynecology/Section Gynecologic Oncology, University of Chicago, Chicago, IL, USA.
Ernst LengyelDepartment of Obstetrics and Gynecology/Section Gynecologic Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8624-1507
Douglas G TilleyDepartment of Cardiovascular Sciences, Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9681-3377
Matthias MackDepartment of Internal Medicine, University of Regensburg, Regensburg, Germany.ORCID http://orcid.org/0000-0002-3157-7262
Ronald S RockDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2188-7272
Steven J ChmuraDepartment of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
Everett E VokesDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4319-7424
Sean P Pitroda *Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-3056-7991
Hua Laura Liang *Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5512-8595
Ralph R Weichselbaum *Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA. ralph.weichselbaum@uchospitals.edu.ORCID http://orcid.org/0000-0002-5643-8939
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1MMEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MDeveloping an Oncology Workforce for the 21st Century - Renewal 01K12CA139160 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F., SMITH, SONALI · 2010 to 2024
$10.6MRadiation Effect on Immune Cells and the MicrobiomeU54CA274291 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI John Ng · 2022 to 2026
$9.1MCLINICAL THERAPEUTICST32GM007019 · NIGMS · UNIVERSITY OF CHICAGO · PI Peter Hugh O'Donnell, MARK J RATAIN · 1985 to 2026
$8.7MMedical Scientist National Research Service AwardT32GM150375 · NIGMS · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2023 to 2026
$5.5MMetabolic reprogramming of the tumor microenvironment and therapy resistanceR35CA264619 · NCI · UNIVERSITY OF CHICAGO · PI Ernst Lengyel · 2021 to 2026
$5.2MMolecular Mechanisms of Cytoskeletal Mechanosensory SystemsR01GM149073 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Pablo A. Iglesias, DOUGLAS N ROBINSON · 2023 to 2026
$2.6MElucidating the Roles of RNA m6A readers Y1 and Y2 in radiation-induced immunity and immunotherapyR01CA262508 · NCI · UNIVERSITY OF CHICAGO · PI WEICHSELBAUM, RALPH R · 2021 to 2025
$2.0MThe Molecular Basis for Myosin-10 RegulationR01GM161048 · NIGMS · UNIVERSITY OF CHICAGO · PI ROCK, RONALD S · 2025 to 2025
$1.9MNCI NIH HHS K12 CA139160NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA262508NCI NIH HHS R35 CA264619NCI NIH HHS U54 CA274291NIEHS NIH HHS P30 ES027792NIGMS NIH HHS R01 GM149073NIGMS NIH HHS R01 GM161048NIGMS NIH HHS T32 GM007019NIGMS NIH HHS T32 GM007281NIGMS NIH HHS T32 GM150375
Abstract
The anti-tumour effect of radiotherapy beyond the treatment field-the abscopal effect-has garnered much interest
Indexed as
AmphiregulinNeoplasm MetastasisAnimalsCell Line, TumorErbB ReceptorsFemaleHumansImmune ToleranceLigandsMaleMiceMyeloid CellsPhagocytosisAmphiregulinAREG protein, humanAreg protein, mouseErbB ReceptorsLigands
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.