Evidence map›Paper›PMID 40368936›Full record

ArticleNature communications2025

Selective radical-type perfluoro-tert-butylation of unsaturated compounds with a stable and scalable reagent.

Ruitong Zhang, Shengqi Zhou, Yijing Li, Yaxing Wu, Xiangyu Chen, Fei Wang, Yunchen Jiang, Xingwei Guo, Chao Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruitong ZhangKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China.ORCID http://orcid.org/0009-0000-9804-9336
Shengqi ZhouCenter of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China.
Yijing LiKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China.
Yaxing WuKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China.ORCID http://orcid.org/0000-0003-2091-7679
Xiangyu ChenKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China.ORCID http://orcid.org/0009-0003-7562-4942
Fei WangKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China.ORCID http://orcid.org/0000-0002-5933-5230
Yunchen JiangKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China.
Xingwei GuoCenter of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China. guoxw@sustech.edu.cn.ORCID http://orcid.org/0000-0002-5461-0360
Chao ChenKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing, 100084, PR China. chenchao01@mails.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-7644-0884

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22071129
6 · The paper itself

Abstract

Despite the promising potential of the perfluoro-tert-butyl group in diverse fields such as magnetic resonance imaging, material science and drug design, incorporating this group into organic molecules is still a formidable task, primarily due to its bulky structure and unique fluorine effect. Herein, we describe a stable and scalable reagent for radical-type perfluoro-tert-butylation, which is synthesized in large scale from commercial perfluoro-tert-butanol and a designed benzothiazole hypervalent iodonium salt. Highly E-selective photo-driven C(sp

Identifiers

PMID40368936
PMCPMC12078615

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.