ArticleNature communications2025
Developing brain asymmetry shapes cognitive and psychiatric outcomes in adolescence.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Modelling post-traumatic stress disorder-major depressive disorder comorbidity in rats: impaired α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor signalling is consistent with synergistic behavioural and cognitive deficits.European journal of psychotraumatology · 2026Article
- What makes a lonely child: environmental, health, and multimodal neuroimaging correlates of prospective loneliness in the ABCD study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Domain-general and language-specific brain networks are differentially associated with verbal intelligence during development.iScience · 2026Article
- Prenatal and early-life determinants of neurodevelopment: A decade of discoveries and new directions in ABCD.Developmental cognitive neuroscience · 2026Review
- Development and validation of a diagnostic model for mild cognitive impairment in patients with type 2 diabetes mellitus and concomitant white matter hyperintensities.BMC neurology · 2026Article
- Next-Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS.Cell proliferation · 2026Review
- An interpretable cross-attentive multi-modal MRI fusion framework for schizophrenia identification.Neuroimage. Reports · 2026Article
- Diagnostic Differentiation Between Unipolar and Bipolar Depression: A Machine Learning Analysis of Demographic and Clinical Features.Alpha psychiatry · 2026Article
- Differential roles of peer bullying and childhood maltreatment in suicidal ideation and attempts among Chinese adolescents.Child and adolescent psychiatry and mental health · 2026Article
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- Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior.Nature communications · 2026Article
- Mapping corpus callosum architecture: developmental, genetic, and cognitive correlates in youth.bioRxiv : the preprint server for biology · 2026Article
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- Noradrenergic activity as a key target in modulating consciousness.Scientific reports · 2026Article
- Study on the construction of a predictive model for delayed encephalopathy after acute carbon monoxide poisoning.BMC neurology · 2026Article
- MULTI-MODAL AND MULTI-REGION DISTANCE MODEL FOR NEUROIMAGING: APPLICATION TO ABCD STUDY.bioRxiv : the preprint server for biology · 2026Article
- Resting-state brain network alterations in spinal cord injury patients: an fNIRS study.Frontiers in human neuroscience · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors.
Funding
Abstract
Cerebral asymmetry, fundamental to various cognitive functions, is often disrupted in neuropsychiatric disorders. While brain growth has been extensively studied, the maturation of brain asymmetry in children and the factors influencing it in adolescence remain poorly understood. We analyze longitudinal data from 11,270 children aged 10-14 years in the Adolescent Brain Cognitive Development (ABCD) study. Our analysis maps the developmental trajectory of structural brain asymmetry. We identify significant age-related, modality-specific development patterns. These patterns link to crystallized intelligence and mental health problems, but with weak correlations. Genetically, structural asymmetry relates to synaptic processes and neuron projections, likely through asymmetric synaptic pruning. At the microstructural level, corpus callosum integrity emerged as a key factor modulating the developing asymmetry. Environmentally, favorable perinatal conditions were associated with prolonged corpus callosum development, which affected future asymmetry patterns and cognitive outcomes. These findings underscore the dynamic yet predictable interactions between brain asymmetry, its structural determinants, and cognitive and psychiatric outcomes during a pivotal developmental stage. Our results provide empirical support for the adaptive plasticity theory in cerebral asymmetry and offer insights into both cognitive maturation and potential risk for early-onset mental health problems.
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