Evidence map›Paper›PMID 40368906›Full record

ArticleNature communications2025

Differential regulation of fetal bone marrow and liver hematopoiesis by yolk-sac-derived myeloid cells.

Benjamin Weinhaus, Shelli Homan, Morgan Kincaid, Aryan Tadwalkar, Xiaowei Gu, Sumit Kumar, Anastasiya Slaughter, Jizhou Zhang, Qingqing Wu, J Matthew Kofron and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Benjamin WeinhausDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.
Shelli Homan *Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.
Morgan Kincaid *Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.
Aryan TadwalkarDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0009-0003-2069-5583
Xiaowei GuReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0000-0001-5666-2562
Sumit KumarDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.
Anastasiya SlaughterDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.
Jizhou ZhangDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.
Qingqing WuDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA.
J Matthew KofronDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Ty D TroutmanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.ORCID http://orcid.org/0000-0001-8925-8080
Tony DeFalcoReproductive Sciences Center, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.ORCID http://orcid.org/0000-0003-4133-7040
Daniel LucasDivision of Experimental Hematology and Cancer Biology, Cincinnati Children's Medical Center, Cincinnati, OH, 45229, USA. daniel.lucas@cchmc.org.ORCID http://orcid.org/0000-0002-0147-5425

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON · 2007 to 2026
$24.4M
Xenotransplant and Genome Editing CoreU54DK126108 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Daniel Starczynowski, YI ZHENG · 2021 to 2026
$5.0M
Role of the local vascular microenvironment in the bone marrow response to inflammationR01HL158616 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LUCAS, DANIEL · 2021 to 2024
$2.3M
The microenvironment in bone marrow hematopoiesisR35HL177125 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Daniel Lucas · 2025 to 2026
$2.2M
Spatial Control of Myeloid DifferentiationR01HL153229 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LUCAS, DANIEL · 2021 to 2024
$2.0M
Macrophage regulation of the spermatogonial stem cell nicheR35GM119458 · NIGMS · CINCINNATI CHILDRENS HOSP MED CTR · PI DEFALCO, TONY J. · 2016 to 2020
$1.9M
Exploring vascular-mesenchymal interactions in the stem cell nicheR01HD094698 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI DEFALCO, TONY J. · 2018 to 2022
$1.6M
Cellular crosstalk in the hematopoietic microenvironmentR01HL136529 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LUCAS, DANIEL · 2018 to 2021
$1.6M
Skeletal heterogeneity of bone marrow stress responses.R01DK141465 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Daniel Lucas · 2024 to 2026
$1.5M
SH800 Cell SorterS10OD023410 · OD · CINCINNATI CHILDRENS HOSP MED CTR · PI THORNTON, SHERRY L · 2017 to 2017
$318k
American Association for the Study of Liver Diseases (AASLD) PNC23-216751NHLBI NIH HHS R01 HL136529NHLBI NIH HHS R01 HL153229NHLBI NIH HHS R01 HL158616NHLBI NIH HHS R35 HL177125NICHD NIH HHS R01 HD094698NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK141465NIDDK NIH HHS U54 DK126108NIGMS NIH HHS R35 GM119458NIH HHS S10 OD023410U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R35HL177125U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 1R01DK141465-01U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) NIH P30 DK078392
6 · The paper itself

Abstract

Fetal hematopoiesis takes place in the liver before colonizing the bone marrow where it will persist for life. This colonization is thought to be mediated by specification of a microenvironment that selectively recruits hematopoietic cells to the nascent bone marrow. The identity and mechanisms regulating the specification of this colonization niche are unclear. Here we identify a VCAM1

Indexed as

Bone MarrowHematopoiesisLiverMyeloid CellsYolk SacAnimalsFemaleFetusHematopoietic Stem CellsMiceMice, Inbred C57BLNeutrophilsOsteoclastsVascular Cell Adhesion Molecule-1Vascular Cell Adhesion Molecule-1

Identifiers

PMID40368906
PMCPMC12078524

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.