Evidence map›Paper›PMID 40368863›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2025

[Effect of stretch on taurine upregulated gene 1-mediated miR-545-3p/cannbinoida receptor 2 pathway regulating distraction osteogenesis in rats].

Mengzhu Zhang, Bin Wang, Zixin Wang, Yalong Wu, Yongxin Zheng

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mengzhu ZhangDepartment of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan Hebei, 063000, P. R. China.
Bin WangDepartment of Orthopedics, , the Second Hospital of Tangshan, Tangshan Hebei, 063000, P. R. China.
Zixin WangDepartment of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan Hebei, 063000, P. R. China.
Yalong WuDepartment of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan Hebei, 063000, P. R. China.
Yongxin ZhengDepartment of Orthopedics, Affiliated Hospital of North China University of Science and Technology, Tangshan Hebei, 063000, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effect of stretch on long non-coding RNA taurine upregulated gene 1 (TUG1)-mediated miR-545-3p/cannbinoida receptor 2 (CNR2) pathway regulating bone regeneration in the distraction area of rats during distraction osteogenesis. Methods: Thirty-six 10-week-old male Sprague Dawley rats were randomly divided into 3 groups ( Results: The results of X-ray film and HE staining observations showed that osteogenesis in group C was superior to groups A and B at the same time point. The results of qRT-PCR showed that the relative mRNA expressions of TUG1, CNR2, ALP, OCN, and OPN in group C were significantly higher than those in group A and group B, and the relative mRNA expression of miR-545-3p in group C was significantly lower than that in group A and group B ( Conclusion: Under the action of stretch, the expression of TUG1 in the femoral distraction area of rats increases, which promotes the expression of CNR2 by inhibiting the expression of miR-545-3P, which is helpful to the mineralization of the extension area and osteogenesis.

Indexed as

Bone RegenerationMicroRNAsOsteogenesis, DistractionRNA, Long NoncodingAlkaline PhosphataseAnimalsFemoral FracturesMaleOsteoblastsOsteocalcinOsteogenesisOsteopontinRatsRats, Sprague-DawleyRNA, Small InterferingSignal TransductionAlkaline PhosphataseMicroRNAsOsteocalcinOsteopontinRNA, Long NoncodingRNA, Small InterferingTUG1 long noncoding RNA, ratcannbinoida receptor 2Distraction osteogenesismineralization of distraction arearatstretchtaurine upregulated gene 1

Identifiers

PMID40368863
PMCPMC12091737

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.