Evidence map›Paper›PMID 40368788›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Latent Tubulointerstitial Nephritis with IgM-positive Plasma Cells Uncovered in a Case of IgA Nephropathy and Primary Biliary Cholangitis: Clinical and Histological Insights.

Ryosuke Saiki, Kan Katayama, Enyo Akiyama, Keiko Oda, Yasuo Suzuki, Tomohiro Murata, Naoki Takahashi, Kaoru Dohi

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryosuke SaikiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Kan KatayamaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Enyo AkiyamaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Keiko OdaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Yasuo SuzukiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Tomohiro MurataDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.
Naoki TakahashiDepartment of Nephrology, Faculty of Medical Science, University of Fukui, Japan.
Kaoru DohiDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with anti-mitochondrial antibody positivity rarely develop tubulointerstitial nephritis with IgM-positive plasma cells (IgMPC-TIN). A previous report observed elevated serum IgM and urinary β2 microglobulin levels in all cases of IgMPC-TIN. This case involved IgA nephropathy with latent coexisting IgMPC-TIN; however, no such changes were observed. These results suggest that some patients with primary biliary cholangitis may have latent IgMPC-TIN without specific urine or blood results. Furthermore, the patient simultaneously developed IgA nephropathy and IgMPC-TIN, suggesting that the triggers and exacerbating factors for both conditions share a common underlying cause.

Indexed as

Glomerulonephritis, IGAImmunoglobulin MLiver Cirrhosis, BiliaryNephritis, InterstitialPlasma CellsAdultFemaleHumansMaleMiddle AgedImmunoglobulin Manti-mitochondrial antibodyIgA nephropathytubulointerstitial nephritis with IgM-positive plasma cells

Identifiers

PMID40368788
PMCPMC12702556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.