Evidence map›Paper›PMID 40368785›Full record

ReviewInternal medicine (Tokyo, Japan)2025

High-grade and Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas with STK11 Aberration Having Undergone Pancreatic Resection Three Times for Metachronous Intrapancreatic Recurrences: A Case Report and Review of the Literature.

Hideyuki Anan, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Hiroaki Kusunose, Toshitaka Sakai, Keisuke Yonamine, Kazuaki Miyamoto, Fumisato Kozakai, Haruka Okano and 9 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Hideyuki AnanDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Shinsuke KoshitaDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Yoshihide KannoDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Takahisa OgawaDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Hiroaki KusunoseDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Toshitaka SakaiDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Keisuke YonamineDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Kazuaki MiyamotoDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Fumisato KozakaiDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Haruka OkanoDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Kento HosokawaDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Masaya OikawaDepartment of Surgery, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Takashi TsuchiyaDepartment of Surgery, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Yutaka NodaDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Takashi SawaiDepartment of Pathology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.
Taito ItohDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Japan.
Yuko OmoriDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Japan.
Toru FurukawaDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Japan.
Kei ItoDepartment of Gastroenterology, Public Interest Incorporated Foundation Sendai City Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 56-year-old woman with high-grade or invasive intraductal papillary mucinous neoplasm (IPMN) underwent 3 pancreatic surgeries for initial and recurrent IPMN lesions. Immunostaining and genetic analyses of all lesions revealed a consistent mutation in KRAS and loss of serine/threonine kinase 11 (STK11), indicating the same origin of these lesions and the possibility of intraductal dissemination. Other immunostaining findings, such as mucin expression and a high Ki-67 labeling index, were consistent among all the lesions and supported their malignant potential. IPMNs with loss of STK11 may benefit from tailored follow-up of the remnant pancreas due to their high likelihood of recurrence through intraductal spread.

Indexed as

Adenocarcinoma, MucinousAMP-Activated Protein Kinase KinasesNeoplasm Recurrence, LocalPancreatectomyPancreatic Intraductal NeoplasmsReoperationFemaleHumansMiddle AgedMutationNeoplasm GradingPancreasAMP-Activated Protein Kinase KinasesSTK11 protein, humanintraductal disseminationIPMNrecurrenceSTK11

Identifiers

PMID40368785
PMCPMC12702538

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.