ArticleInternal medicine (Tokyo, Japan)2025
An Autopsied Case of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids for Over Four Years.
Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare inflammatory disease of the central nervous system, and many details, including pathological findings, are still unclear. We herein report a man in his 70s who had been diagnosed with CLIPPERS 4.5 years ago. He was treated with corticosteroids, and his symptoms were managed; however, he eventually died of coronavirus disease 2019. A postmortem autopsy revealed perivascular lymphocyte aggregation and demyelination centered in the brainstem and cerebellum. This is the world's first autopsied case of CLIPPERS with more than four years of follow-up.
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