Evidence map›Paper›PMID 40368280›Full record

ReviewCurrent opinion in insect science2025

Mosquito sex determination: recent advances and applications.

Melanie Hempel, Joseph D Warren, Jiangtao Liang, Christen Hughes, Zhijian Tu

Abstract readReview
In one paragraph

Review in Current opinion in insect science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Rapid turnover of sex-determining architecture in invasive mussels.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melanie HempelDepartment of Biochemistry and the Fralin Life Sciences Institute Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: melanieh20@vt.edu.
Joseph D WarrenDepartment of Biochemistry and the Fralin Life Sciences Institute Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: warrenjosephd@vt.edu.
Jiangtao LiangDepartment of Biochemistry and the Fralin Life Sciences Institute Virginia Tech, Blacksburg, VA 24061, USA.
Christen HughesDepartment of Biochemistry and the Fralin Life Sciences Institute Virginia Tech, Blacksburg, VA 24061, USA.
Zhijian TuDepartment of Biochemistry and the Fralin Life Sciences Institute Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: jaketu@vt.edu.

Funding

Sex ratio distortion in Aedes aegyptiR01AI157491 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2020 to 2024
$3.1M
Sex determination and the sex-determining locus in aedine mosquitoesR01AI179056 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Zhijian Jake Tu · 2023 to 2026
$3.0M
The male-determining locus of Culex quinquefasciatusR21AI154871 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI TU, ZHIJIAN JAKE · 2020 to 2021
$438k
NIAID NIH HHS R01 AI157491NIAID NIH HHS R01 AI179056NIAID NIH HHS R21 AI154871
6 · The paper itself

Abstract

Mosquitoes have evolved divergent sex-determining chromosomes, and they employ diverse primary signals for sex determination. As only females feed on vertebrate blood, manipulating genes involved in sex determination can facilitate genetic control measures for mosquito-borne infectious diseases, such as dengue and malaria. We highlight new advances in mosquito sex determination, describe innovative applications, and discuss relevant evolutionary insights and future directions.

Indexed as

CulicidaeSex Determination ProcessesAnimalsFemaleMale

Identifiers

PMID40368280
PMCPMC12331425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.