Evidence map›Paper›PMID 40368269›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2025

Paraoxonase 3 regulates the pore-forming α subunit of the large-conductance K

Sarah Christine M Whelan, Andrew J Nickerson, Nicolas Montalbetti, Stephanie M Mutchler, Marcelo D Carattino, Thomas R Kleyman, Shujie Shi

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah Christine M WhelanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Andrew J NickersonDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Nicolas MontalbettiDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Stephanie M MutchlerDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Marcelo D CarattinoDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
Shujie ShiDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: shs117@pitt.edu.

Funding

Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gerard L Apodaca · 2023 to 2026
$4.8M
Regulation of ENaC Trafficking and Activity in the KidneyR01DK111380 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI PALMER, LAWRENCE G · 2017 to 2025
$3.1M
Role of piezo channels in intercalated cellsR01DK129285 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R, SATLIN, LISA M. · 2022 to 2025
$2.3M
Degenerin and TrpC6 channels in renal vascular mechanosesnsor signaling and protection against injury.R01DK137167 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Heather A Drummond, Thomas R Kleyman · 2024 to 2026
$1.8M
Role of PON3 in regulating renal Na+ and K+ homeostasisR01DK130901 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2021 to 2025
$1.6M
Role of acid-sensing ion channels in bladder sensory signalingR01DK134431 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2023 to 2025
$941k
Leica Stellaris Confocal for Kidney Imaging CoreS10OD028596 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2021
$596k
NIDDK NIH HHS R01 DK111380NIDDK NIH HHS R01 DK129285NIDDK NIH HHS R01 DK130901NIDDK NIH HHS R01 DK134431NIDDK NIH HHS R01 DK137167NIDDK NIH HHS U54 DK137329NIH HHS S10 OD028596
6 · The paper itself

Abstract

Paraoxonase 3 (PON3) is expressed in the aldosterone-sensitive distal nephron (ASDN) where the fine tuning of Na

Indexed as

AryldialkylphosphataseLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsAnimalsHEK293 CellsHumansMaleMiceMice, KnockoutNephronsPotassiumAryldialkylphosphataseLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsPotassiumBKChaperoneKidneyPON3Potassium

Identifiers

PMID40368269
PMCPMC12163985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.