ArticleMolecular metabolism2025
Reduced liver mitochondrial energy metabolism impairs food intake regulation following gastric preloads and fasting.
Article in Molecular metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The Impact of a Western Diet with High Salt on Metabolic Outcomes in Male C57bl/6J Mice.bioRxiv : the preprint server for biology · 2025Article
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Abstract
objectiveThe capacity of the liver to serve as a peripheral sensor in the regulation of food intake has been debated for over half a century. The anatomical position and physiological roles of the liver suggest it is a prime candidate to serve as an interoceptive sensor of peripheral tissue and systemic energy state. Importantly, maintenance of liver ATP levels and within-meal food intake inhibition is impaired in human subjects with obesity and obese pre-clinical models. Previously, we have shown decreased hepatic mitochondrial energy metabolism (i.e., oxidative metabolism & ADP-dependent respiration) in male liver-specific, heterozygous PGC1a mice results in increased short-term diet-induced weight gain with increased within meal food intake. Herein, we tested the hypothesis that decreased liver mitochondrial energy metabolism impairs meal termination following nutrient oral pre-loads.
methodsLiver mitochondrial respiratory response to changes in ΔG
resultsWe observed male liver-specific, heterozygous PGC1a mice have reduced mitochondrial response to changes in ΔG
conclusionsThese data support previous work proposing liver-mediated food intake regulation through modulation of peripheral satiation signals.
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