Evidence map›Paper›PMID 40368025›Full record

ArticleContemporary clinical trials2025

Assessing the effect of virtual navigation interventions to improve health insurance literacy and decrease financial burden in cancer survivors: The HINT II study protocol.

Elyse R Park, Anne C Kirchhoff, Calli O Mitchell, Natalie Durieux, Allyson Foor, Karen Kuhlthau, Giselle K Perez, Lakisa Ards, Shani Alston, Gregory T Armstrong and 10 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05527392 (Assessing the Effect of Virtual Navigation Interventions to Improve Health Insurance Literacy and Decrease Financial Burden), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05527392 naactive not recruitingnot on this map

Assessing the Effect of Virtual Navigation Interventions to Improve Health Insurance Literacy and Decrease Financial Burden: A Childhood Cancer Survivor Study Randomized Trial (HINTII)

TypeinterventionalSponsorMassachusetts General HospitalRan2023 to 2027Enrolled529ConditionsChildhood Cancer SurvivorsArmsHealth Insurance Navigation Tools Program
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Development of a Health Insurance Navigation Program for Long-Term Childhood Cancer Survivors.Health education & behavior : the official publication of the Society for Public Health Education · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Elyse R ParkDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Mongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA; Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA. Electronic address: epark@mgh.harvard.edu.
Anne C KirchhoffUniversity of Utah Health Huntsman Cancer Institute, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA.
Calli O MitchellMongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA; Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA.
Natalie DurieuxMongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA; Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA.
Allyson FoorMongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA.
Karen KuhlthauDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Mongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA; Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA.
Giselle K PerezDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Mongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA; Health Promotion and Resiliency Intervention Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA.
Lakisa ArdsSt. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Shani AlstonSt. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Gregory T ArmstrongSt. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Perla L Vaca LopezUniversity of Utah Health Huntsman Cancer Institute, 2000 Circle of Hope Drive, Salt Lake City, UT 84112, USA.
Aaron McDonaldSt. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Vikki G NolanSt. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Douglas E LevyMongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.
Wendy M LeisenringFred Hutchinson Cancer Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
Alison A GalbraithBoston Medical Center, One Boston Medical Center Place, Boston, MA 02118, USA; Boston University Chobanian and Avedisian School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Paul C NathanThe Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.
Chris VukadinovichSt. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Christie L CooperSt. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Karen DonelanDepartment of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Mongan Institute Health Policy Research Center, Massachusetts General Hospital, 100 Cambridge Street, Suite 1600, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
Assessing the effect of virtual navigation interventions to improve health insurance literacy and decrease financial burden: A CCSS randomized trialR01CA271380 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Anne C Kirchhoff, Elyse R. Park · 2022 to 2026
$3.8M
NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA271380NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

backgroundChildhood cancer survivors often face high healthcare costs to monitor and manage new or lasting effects of their treatment. Enhancing survivors' health insurance literacy (HIL) - the knowledge, ability, and confidence in enrolling in and navigating health plans - is vital for minimizing financial burden. Few studies have assessed the effect of a health insurance navigation program on improving HIL among survivors. We present the protocol for an ongoing randomized controlled trial (RCT) assessing the effectiveness of two health insurance navigation programs (HINT-S and HINT-A) on improving HIL, financial burden, out-of-pocket costs, and healthcare utilization for adult survivors of childhood cancer.

methodsThis three-arm RCT assesses the effectiveness of two digitally delivered health insurance navigation interventions and enhanced usual care (EUC) on improving HIL at six and 12 months in a national cohort of childhood cancer survivors. While HINT-S is composed of five synchronous, navigator-led sessions, HINT-A is an asynchronous, prerecorded set of five videos. EUC participants receive only a health insurance informational booklet. Financial burden, medical out-of-pocket costs, and healthcare utilization (receipt of preventive care, recommended screenings/vaccinations, and acute care) are assessed at 12 months. Moderators to the interventions' effectiveness will be investigated, as well as implementation outcomes (feasibility, acceptability, appropriateness, fidelity, and cost-effectiveness).

conclusionsThere is a strong need for interventions to improve cancer survivors' HIL, helping them navigate the complexity of the U.S. healthcare system. This trial will elucidate the potential effectiveness and implementation of health insurance navigation programs that may benefit many cancer survivors.

trial registrationNCT05527392.

Indexed as

Cancer SurvivorsHealth LiteracyInsurance, HealthNeoplasmsPatient NavigationAdultCost of IllnessHealth ExpendituresHumansMalePatient Acceptance of Health CareRandomized Controlled Trials as Topic

Identifiers

PMID40368025
PMCPMC12175485

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.