Evidence map›Paper›PMID 40367949›Full record

ArticleImmunity2025

Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses.

Vincent Guichard, Felipe Batista Leão, Jingyao Zhao, Yingyu Zhang, Takamasa Ito, Simon Shirley, Thomas S Postler, Ruxiao Tian, Yuefeng Huang, Sankar Ghosh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. HuR Regulates GATA3-Driven Type 2 Inflammation in CD4bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vincent GuichardDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Felipe Batista LeãoDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Jingyao ZhaoDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Yingyu ZhangDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Takamasa ItoDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Simon ShirleyDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Thomas S PostlerVaccine Design and Development Laboratory, IAVI, New York, NY 10004, USA.
Ruxiao TianDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Yuefeng HuangDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: yh3102@cumc.columbia.edu.
Sankar GhoshDepartment of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: sg2715@columbia.edu.

Funding

Understanding the role of NF-kB in T-regulatory cell functionR01AI068977 · NIAID · YALE UNIVERSITY · PI GHOSH, SANKAR · 2006 to 2017
$3.9M
Elucidation of the regulation and function of innate lymphoid cellsR35GM138805 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUANG, YUEFENG · 2020 to 2024
$2.1M
NIAID NIH HHS R01 AI068977NIGMS NIH HHS R35 GM138805
6 · The paper itself

Abstract

CD4

Indexed as

Epigenesis, GeneticLymphocytesNF-kappa BTh2 CellsAnimalsGene Expression RegulationImmunity, InnateInterleukin-33Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellSignal TransductionTranscription Factor RelAInterleukin-33NF-kappa BReceptors, Antigen, T-CellTranscription Factor RelAc-relIl-13Il-33Il-4Il-5ILC2NF-κBp65Th2type 2 cytokines

Identifiers

PMID40367949
PMCPMC12626339

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.