Evidence map›Paper›PMID 40367942›Full record

ArticleNeuron2025

Presynaptic α

William Milanick, Jianing Li, Connon I Thomas, Mohammed Al-Yaari, Debbie Guerrero-Given, Naomi Kamasawa, Samuel M Young

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

William MilanickGene Therapy Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA; Interdisciplinary Graduate Program in Neuroscience, University of Iowa, Iowa City, IA 52242, USA.
Jianing LiGene Therapy Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Connon I ThomasThe Imaging Center and Electron Microscopy Core Facility, Max Planck Institute for Neuroscience, Jupiter, FL 33458, USA.
Mohammed Al-YaariGene Therapy Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Debbie Guerrero-GivenThe Imaging Center and Electron Microscopy Core Facility, Max Planck Institute for Neuroscience, Jupiter, FL 33458, USA.
Naomi KamasawaThe Imaging Center and Electron Microscopy Core Facility, Max Planck Institute for Neuroscience, Jupiter, FL 33458, USA.
Samuel M YoungGene Therapy Center, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pediatrics, Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: samuel_young@med.unc.edu.

Funding

Regulation of Synaptic Vesicle Dynamics in the Auditory SystemR01DC014093 · NIDCD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNG, SAMUEL MATTHEW · 2015 to 2024
$3.7M
Presynaptic regulation of neurotransmitter release in mammalian neuronal circuitsR01NS110742 · NINDS · UNIVERSITY OF IOWA · PI YOUNG, SAMUEL MATTHEW · 2020 to 2024
$1.7M
Elucidating the roles of CACNA2D2 and CACNA2D3 in presynaptic regulation of mammalian synaptic functionR03TR004161 · NCATS · UNIVERSITY OF IOWA · PI YOUNG, SAMUEL MATTHEW · 2022 to 2022
$155k
NCATS NIH HHS R03 TR004161NIDCD NIH HHS R01 DC014093NINDS NIH HHS R01 NS110742
6 · The paper itself

Abstract

The α

Indexed as

BrainCalcium ChannelsPresynaptic TerminalsSynapsesAnimalsMiceMice, KnockoutNerve Tissue ProteinsNeuronal PlasticityCACNA2D1 protein, mouseCalcium ChannelsNerve Tissue Proteinsactive zonecalcium channelsneurological disordersneuronal circuitsneurotransmitter releasesynapsesynapse developmentsynaptic plasticitysynaptic transmissionsynaptogenesis

Identifiers

PMID40367942
PMCPMC12181065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.