Evidence map›Paper›PMID 40367708›Full record

ArticleThe Journal of surgical research2025

Thromboelastography Use: Sex, a Possible Predictor of Thrombosis in Peripheral Artery Disease.

Savo Bou Zein Eddine, Katherine Morrow, Vahe Panossian, Sasha Suarez Ferreira, Shiv Patel, Fanah Hagos, Adriana Araceli Rodriguez, Tasya Rakasiwi, Anahita Dua

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Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Savo Bou Zein EddineDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Katherine MorrowDivision of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Vahe PanossianDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Sasha Suarez FerreiraDivision of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Shiv PatelDivision of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Fanah HagosDivision of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Adriana Araceli RodriguezDivision of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Tasya RakasiwiDivision of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Anahita DuaDivision of Vascular and Endovascular Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: adua1@mgh.harvard.edu.

Funding

Preventing Graft Thrombosis in the Elderly through Development of a Risk Prediction ToolR21AG077310 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DUA, ANAHITA · 2022 to 2023
$476k
NIA NIH HHS R21 AG077310
6 · The paper itself

Abstract

introductionThrombosis of bypass grafts or stents postrevascularization procedures of lower extremities is a leading cause of amputation and higher morbidity in patients with peripheral artery disease (PAD). The aim of this study is to evaluate the relationship between sex and the risk of postrevascularization thrombosis in patients with PAD.

methodsPatient undergoing procedures between January 2021 and July 2023 underwent preoperative thromboelastography-platelet mapping (TEG-PM) analysis and were prospectively observed up to POD#60 to evaluate intervention-related thrombosis. A multivariable logistic regression analysis was carried out to assess if sex is an independent predictor of the above outcome and what specific coagulation parameters differed between the two.

resultsA total of 177 TEG-PM preoperative samples from patients were analyzed. Sixty-three (35.6%) were females. Of whom, only nine (14.2%) had >30% adenosine diphosphate-platelet inhibition, 15 (23.8%) received anticoagulation within 24 h of the intervention, and 6 (9.5%) had intervention-related thrombosis with no significant differences in baseline thrombosis risk factors. A total of 38 (21.5%) patients received anticoagulation within 24 h of the intervention. On multivariable logistic regression, females did not have a significant association with of having an intervention-related thrombotic event compared with males (odds ratio 0.19, 95% confidence interval 0.03-1.12; P = 0.067).

conclusionsThere is significant variation between the treatment patterns in patients postrevascularization. Sex may be associated with the risk of thrombosis, but this can be modulated by appropriate, individualized therapy guided by TEG-PM. A larger study population is needed to better identify the independent predictors of thrombotic events.

Indexed as

Peripheral Arterial DiseasePostoperative ComplicationsThrombelastographyThrombosisAgedAged, 80 and overAnticoagulantsFemaleHumansMaleMiddle AgedPlatelet Aggregation InhibitorsProspective StudiesRisk AssessmentRisk FactorsSex FactorsAnticoagulantsPlatelet Aggregation InhibitorsCoagulationPeripheral arterial diseaseThromboelastographyThromboelastography with platelet mapping

Identifiers

PMID40367708
PMCPMC12162203

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