Evidence map›Paper›PMID 40367373›Full record

ArticleThe New England journal of medicine2025

Loss of Subsidized Drug Coverage and Mortality among Medicare Beneficiaries.

Eric T Roberts, Jessica Phelan, Aaron L Schwartz, Ellen Meara, Dominic Ruggiero, Lilly Estenson, Rachel M Werner, José F Figueroa

Abstract read
In one paragraph

Article in The New England journal of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  7. Exploring the Impact of Financial Toxicity in COPD: A Qualitative Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Estimating US savings on outpatient prescription pharmaceuticals from international reference pricing.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eric T RobertsPerelman School of Medicine and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.
Jessica PhelanHarvard T.H. Chan School of Public Health, Boston.
Aaron L SchwartzPerelman School of Medicine and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.
Ellen MearaHarvard T.H. Chan School of Public Health, Boston.ORCID 0000-0003-0211-1970
Dominic RuggieroPerelman School of Medicine and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.ORCID 0000-0002-9972-9349
Lilly EstensonLeonard Davis School of Gerontology, University of Southern California, Los Angeles.
Rachel M WernerPerelman School of Medicine and Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.
José F FigueroaHarvard T.H. Chan School of Public Health, Boston.

Funding

RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
Racial/Ethnic Disparities in Medicare Advantage vs. Traditional Medicare: Evidence to Improve Equity in MedicareR01AG076437 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Z. AYANIAN, Eric T Roberts · 2022 to 2026
$2.8M
Integrated Care Plans and Health Care Quality, Outcomes, and Equity for Medicare-Medicaid Dual Eligible Beneficiaries with Multimorbidity, Frailty, or DementiaRF1AG088640 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FIGUEROA, JOSE FRANCISCO · 2024 to 2024
$2.3M
Improving Healthcare Quality For Older Adults with HIV Under Value-Based Care ModelsR01AG081151 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FIGUEROA, JOSE FRANCISCO · 2023 to 2025
$2.2M
AHRQ HHS R01 HS029453AHRQ HHS R01HS029453NIA NIH HHS R01 AG076437NIA NIH HHS R01AG076437NIA NIH HHS R01 AG081151NIA NIH HHS R01AG081151NIA NIH HHS RF1 AG088640NIA NIH HHS RF1AG088640NIA NIH HHS T32 AG000037NIA NIH HHS T32AG000037
6 · The paper itself

Abstract

backgroundA total of 14 million Medicare beneficiaries receive the Low-Income Subsidy (LIS), which reduces cost sharing in Medicare Part D. Losing the LIS may impede medication access and affect mortality.

methodsUsing 2015-2023 Medicare data, we identified dual-eligible Medicare-Medicaid beneficiaries, who automatically receive the LIS, and calculated annual rates of Medicaid and LIS loss. To examine the relationship between LIS loss and mortality, we leveraged a natural experiment arising from the relationship between the timing of Medicaid disenrollment and subsequent LIS loss. We compared beneficiaries disenrolling from Medicaid in January through June, who kept the LIS through December (6 to 11 additional months), with those disenrolling in July through December, who kept the LIS through the following December (12 to 17 additional months). Among persons disenrolling from Medicaid during 2015-2017, we examined cumulative mortality 7 to 17 months after disenrollment, when those with earlier disenrollment were more likely to lose the LIS.

resultsThe sample included 969,606 persons with early (January though June) Medicaid disenrollment and 920,158 with late (July though December) Medicaid disenrollment. Those with early Medicaid disenrollment averaged 13.6 cumulative months of the LIS in the 17 months after disenrollment, as compared with 15.3 months for those with late disenrollment. At 17 months after Medicaid disenrollment, cumulative mortality was higher among persons with early disenrollment (78.3 per 1000) than among those with late disenrollment (75.3 per 1000), a difference of 3.0 deaths per 1000 (95% confidence interval [CI], 2.1 to 3.9). Mortality differences between persons with early disenrollment and those with late disenrollment were amplified among those in the highest quintile of baseline Part D spending (5.6 deaths per 1000; 95% CI, 3.3 to 7.9) and users of medications for cardiovascular disease, chronic lung disease, or human immunodeficiency virus infection.

conclusionsLoss of drug subsidies after Medicaid disenrollment was associated with higher mortality among low-income Medicare beneficiaries. (Funded by the National Institute on Aging and others.).

Indexed as

Dual Medicare Medicaid EligibilityInsurance CoverageMedicare Part DMortalityAgedAged, 80 and overCost SharingFemaleHumansMaleMedicaidMedicareMiddle AgedPovertyRetrospective StudiesUnited States

Identifiers

PMID40367373
PMCPMC12119213

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.