Evidence map›Paper›PMID 40367334›Full record

ArticleJournal of the American Chemical Society2025

Performance-Enhancing Asymmetric Catalysis Driven by Achiral Counterion Design.

Zihang Deng, Jenna L Payne, Mahesh Vishe, Julius E L Jan, Cody M Funk, Jeffrey N Johnston

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zihang DengDepartment of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-5377-7484
Jenna L PayneDepartment of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
Mahesh VisheDepartment of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
Julius E L JanDepartment of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
Cody M FunkDepartment of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
Jeffrey N JohnstonDepartment of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID 0000-0002-0885-636X

Funding

Studies in Amide and Peptide SynthesisR01GM063557 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSTON, JEFFREY NICHOLAS · 2002 to 2022
$4.5M
New Stereoselective Reactions for Chiral Amine SynthesisR01GM084333 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSTON, JEFFREY NICHOLAS · 2009 to 2017
$2.2M
New Methods for Therapeutic DevelopmentR35GM156307 · NIGMS · VANDERBILT UNIVERSITY · PI Jeffrey Nicholas Johnston · 2025 to 2026
$845k
Application of New Amination Reactions to Natural Product and Nonnatural HeterocyR56GM063557 · NIGMS · VANDERBILT UNIVERSITY · PI JOHNSTON, JEFFREY NICHOLAS · 2008 to 2008
$292k
NIGMS NIH HHS R01 GM063557NIGMS NIH HHS R01 GM084333NIGMS NIH HHS R35 GM156307NIGMS NIH HHS R56 GM063557
6 · The paper itself

Abstract

The development of highly enantioselective reactions often requires the adventitious discovery of a promising chiral catalyst and its resource-intensive optimization to high selectivity and generality. We report an approach less dependent on happenstance, whereby the performance of a single chiral ligand is enhanced not by modification of the architecturally complex chiral features but instead by an achiral counteranion. Critical to this strategy and its general application is the tactical development of

Identifiers

PMID40367334
PMCPMC12123621

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.