ArticleScience advances2025
Optimal focused ultrasound lesion location in essential tremor.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neuroimaging in Tremor.Seminars in neurology · 2026Review
- The emerging role of high-intensity focused ultrasound (HIFU) as a symptomatic treatment for Parkinson's disease and essential tremor: a narrative review.Arquivos de neuro-psiquiatria · 2026Review
- Rescue deep brain stimulation for recurrent essential tremor after ventral intermediate nucleus thalamotomy: illustrative cases.Journal of neurosurgery. Case lessons · 2026Article
- A Fully Magnetic Resonance Imaging-Compatible, Nonelectrical System for Near-Real-Time Tremor Monitoring during Magnetic Resonance-Guided Focused Ultrasound.Stereotactic and functional neurosurgery · 2026Article
- Is It Safe to Have Deep Brain Stimulation after MRI-Guided Focused Ultrasound Ablation? A Report of Three Cases and Review of Literature.Stereotactic and functional neurosurgery · 2026Article
- Surgical Treatment of Tremor Syndromes: A Guide to the Clinician.Movement disorders clinical practice · 2026Review
- Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.medRxiv : the preprint server for health sciences · 2026Article
- Tremor Recurrence in MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: DBS vs. Re-lesion.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- From Ablation to Neuromodulation Platform: The Evolving Role of Magnetic Resonance-Guided Focused Ultrasound in Functional Neurosurgery.Journal of clinical neurology (Seoul, Korea) · 2026Review
- 7T MRI quantitative susceptibility mapping for magnetic resonance-guided focused ultrasound thalamotomy: methodology and anatomo-clinical correlations in a retrospective pilot study.Quantitative imaging in medicine and surgery · 2025Article
- From adaptive deep brain stimulation to adaptive circuit targeting.Nature reviews. Neurology · 2025Review
- Direct targeting for focused ultrasound thalamotomy in the treatment of movement disorders: a retrospective cohort study.medRxiv : the preprint server for health sciences · 2025Article
- Sweet and Sour Spots of Focused Ultrasound.Movement disorders clinical practice · 2025Article
- Convergent mapping of a tremor treatment network.Nature communications · 2025Article
- Turning Up the Heat on Temporal Lobe Epilepsy: LAANTERN Helps Illuminate the Role of Laser Ablation.Epilepsy currentsArticle
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an effective treatment for medically refractory essential tremor. We investigate ablation sites and potential tracts associated with optimal tremor control and side effects based on the analysis of 351 cases from three international hospitals. Lesions were segmented on day 1 thin-cut T2 axial images, mapped to standard Montreal Neurological Institute space, and used to derive probabilistic maps and tracts associated with tremor improvement and side effects. Lesioning of a specific subregion within the ventral intermediate nucleus and the cerebellothalamic tract was associated with optimal tremor improvements. Some lesion locations and tracts were associated with differential side effects. Overlaps with the optimal tremor improvement sites accounted for variance in clinical improvements in out-of-sample cases. Efficacy of this location was further confirmed by test-retest cases that underwent two MRgFUS procedures. We identify and validate a target area for optimal tremor control and sites of avoidance associated with side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.