ArticleJournal of cosmetic dermatology2025
Discovery of HY•1: A Novel Multifunctional Skincare Ingredient With Antiaging and Skin Repair Properties.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
objectivesSkin aging, influenced by intrinsic and extrinsic factors, includes photoaging caused by UV radiation, leading to ROS production and skin damage. The objective of this work is to demonstrate HY-1, a three-peptide conjugate shown to have antioxidation, anti-inflammatory efficacy in vitro, and clinical benefits in anti-wrinkle, is an efficacious ingredient for skin aging.
methodThe antioxidation efficacy was studied on the ROS test, and the antiaging efficacy was studied on ex vivo human skin. In the clinical study, 49 subjects aged between 26 and 54 with wrinkle concerns were recruited and instructed to apply the investigational cream containing HY-1 for 28 days. Wrinkle attributes were assessed by dermatologists. Instrumental measurements were also conducted.
resultsIn vitro studies of HY-1 on HSF and HaCaT cells demonstrated significant efficacy in scavenging reactive oxygen species (ROS) and exerting anti-inflammatory effects, as evidenced by decreased ROS production and reduced expression of interleukin-6 (IL-6). Clinical study demonstrated significant improvement in skin condition, including firmness, nourishment, and anti-wrinkle.
conclusionHY-1 is a novel skincare ingredient, addressing the visible manifestations of aging and photodamage. Its multifaceted capabilities, encompassing antioxidant properties, enhancement of skin firmness, nourishment, and anti-wrinkle effects, represent a pioneering approach with the potential to provide a skincare alternative.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.