ArticleEuropean heart journal. Cardiovascular pharmacotherapy2025
Sex-related variations in platelet reactivity in presence or absence of antiplatelet therapy.
Article in European heart journal. Cardiovascular pharmacotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Sex differences among elderly ACS patients undergoing percutaneous coronary intervention receiving Ticagrelor 60 mg vs. 90 mg.Journal of thrombosis and thrombolysis · 2026Trial
- Platelet Reactivity and Sex Differences: Clinical Implications for Women.Circulation research · 2026Review
- Factors associated with aggregate formation in cold-stored platelets.Vox sanguinis · 2026Article
- Managing bleeds on anticoagulant therapy: a practical guide for clinicians.European heart journal. Acute cardiovascular care · 2026Review
- Female Representation in the Antiplatelet Medication Literature Informing the 2023 Canadian Antiplatelet Guidelines.CJC open · 2026Review
- Modern Era in Personalized Medicine of Dual Antiplatelet Therapy After Myocardial Revascularization.Journal of clinical medicine · 2026Review
- ST-elevation myocardial infarction following de-escalation to aspirin monotherapy: evidence of residual platelet function MRP4 overexpression dependent case report.European heart journal. Case reports · 2026Article
- How Sex and Race/Ethnicity Influence Interventional Cardiology Outcomes: What Do We Know?Journal of the Society for Cardiovascular Angiography & Interventions · 2026Review
- Witnessing a possible revolution in antiplatelet therapy for coronary artery bypass grafting.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Seeking for the boundaries of de-escalation in antiplatelet therapy for acute coronary syndrome.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Sex-related differences in platelet aggregation.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Sex-related differences in platelet aggregation: rebuttal to reply.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Reply: sex-related variations in platelet reactivity.European heart journal. Cardiovascular pharmacotherapy · 2025Article
- Entering a new era of antiplatelet therapy: the 4D-ACS trial.European heart journal. Cardiovascular pharmacotherapy · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsEmerging evidence suggests sex-specific differences in platelet biology and clinical responses to antiplatelet agents. Light transmission aggregometry (LTA) represents the historical gold standard for the assessment of platelet reactivity but is influenced by pre-analytical and analytical variables. We analysed a large dataset of patients undergoing LTA using a standardized methodology to investigate the impact of sex on platelet reactivity with or without antiplatelet therapy. METHODS AND
resultsBetween 2004 and 2022, 11,913 patients sequentially underwent LTA assessments following stimulation with adenosine diphosphate (ADP) (2 µM), collagen (2 µg/mL), arachidonic acid (AA, 0.5 mM), and epinephrine (10 µM). After applying study entry criteria, 5687 patients were included: 428 healthy volunteers (HV, F = 273; M = 155), 1055 controls (CTR; F = 725; M = 330), 3289 aspirin-treated patients (ASA; F = 2058; M = 1231), 430 clopidogrel-treated patients (CLOP; F = 272; M = 158), and 485 patients on dual antiplatelet therapy (DAPT; F = 166; M = 319). Within each group, results were analysed and compared between males and females.Females exhibited significantly greater platelet reactivity in response to ADP compared to males in the HV (P = 0.004), CTR (P < 0.0001), ASA (P < 0.0001), and CLOP (P < 0.018) groups, but not in the DAPT group. Among aspirin-treated patients, females showed increased platelet reactivity (P < 0.0001) in response to collagen, compared with males.
conclusionFemales exhibit heightened baseline ADP-dependent platelet reactivity and a diminished response to aspirin and clopidogrel monotherapy compared to males.
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