ArticleeLife2025
Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4
Jie Zhang, Hui Tang, Haoming Wu, Xuewen Pang, Rong Jin, Yu Zhang
Abstract read
In one paragraphArticle in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Jie ZhangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.ORCID https://orcid.org/0000-0003-3338-8139 Hui TangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Haoming WuDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Xuewen PangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Rong JinDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.ORCID https://orcid.org/0000-0002-5666-9497 Yu ZhangDepartment of Immunology, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Medicine Innovation Center for Fundamental Research on Major Immunology-related Diseases, Peking University, Beijing, China.
Funding
Beijing Life Science Academy 2024600CC0080National Key Research and Development Program of China 2023YFB3507000National Natural Science Foundation of China 31872733National Natural Science Foundation of China 32071178National Natural Science Foundation of China 32230037National Natural Science Foundation of China 82394412
6 · The paper itselfAbstract
The newly generated CD4 single-positive (SP) T lymphocytes are featured by enhanced IL-4 but repressed IFN-γ production. The mechanisms underlying this functional bias remain elusive. Previous studies have reported that CD4
Indexed as
CD4-Positive T-LymphocytesDendritic CellsEpigenesis, GeneticInterferon-gammaInterleukinsSTAT1 Transcription FactorThymus GlandAnimalsMiceMice, Inbred C57BLMice, KnockoutThymocytesIl27 protein, mouseInterferon-gammaInterleukinsStat1 protein, mouseSTAT1 Transcription Factorautoimmune diseaseIFN-γIL-27p28immunologyinflammationmousesingle positive thymocyteTh2 bias
Identifiers
PMID40366856
PMCPMC12077877
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