Evidence map›Paper›PMID 40366705›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

Reversal of morphine-induced respiratory depression with the µ

Paulina M Getsy, Walter May, Fraser Henderson, Gregory A Coffee, Santhosh M Baby, Yee-Hsee Hsieh, Stephen J Lewis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mitragynine and 7-hydroxymitragynine: Bidirectional effects on breathing in rats.The Journal of pharmacology and experimental therapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paulina M GetsyDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0001-8278-0810
Walter MayDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, United States.
Fraser HendersonDepartment of Pediatrics, University of Virginia, Charlottesville, Virginia, United States.
Gregory A CoffeeDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.
Santhosh M BabyGalleon Pharmaceuticals, Inc., Horsham, Pennsylvania, United States.
Yee-Hsee HsiehDivision of Pulmonary, Critical Care and Sleep Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, United States.
Stephen J LewisDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0001-7050-0666

Funding

Optimization of novel thioesters as a therapeutic strategy for combating opioid overdoses and abuseU01DA051373 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI LEWIS, STEPHEN JOHN · 2020 to 2022
$1.5M
Galleon Pharmaceuticals, Inc.HHS | NIH | National Institute on Drug Abuse (NIDA) U01DA051373NIDA NIH HHS U01 DA051373
6 · The paper itself

Abstract

The administration of opioid receptor antagonists is believed to overcome ventilatory depressant effects of opioids. Here we show that many ventilatory depressant effects of morphine are converted to excitatory responses after µ

Indexed as

MorphineNaloxoneNarcotic AntagonistsReceptors, Opioid, muRespirationRespiratory InsufficiencyAnalgesics, OpioidAnimalsMaleNaltrexoneRatsRats, Sprague-DawleyAnalgesics, OpioidMorphinenaloxonazineNaloxoneNaltrexonenaltrindoleNarcotic AntagonistsReceptors, Opioid, mumale Sprague Dawley ratsmorphinenaloxonazineventilatory depressionventilatory instability

Identifiers

PMID40366705
PMCPMC12213126

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.