Evidence map›Paper›PMID 40366698›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Structural basis of human Na

Rupam Biswas, Ana Laura López-Serrano, Apoorva Purohit, Angelina Ramirez-Navarro, Hsiang-Ling Huang, Giovanna Grandinetti, Xiaolin Cheng, Sarah M Heissler, Isabelle Deschênes, Krishna Chinthalapudi

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Hypokalaemia and bradycardia unmask the loss-of-function phenotype of a Brugada Syndrome SCN5A mutation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  4. Calcium interaction with Nav1.5 via FGF12A and CaM binding.bioRxiv : the preprint server for biology · 2026
    Article
  5. Characterization of the R893C NaFrontiers in cardiovascular medicine · 2026
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Rupam BiswasDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0001-7732-0115
Ana Laura López-SerranoDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0009-0006-4638-2755
Apoorva PurohitDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-0664-6972
Angelina Ramirez-NavarroDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.
Hsiang-Ling HuangDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.
Giovanna GrandinettiDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.
Xiaolin ChengDivision of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-7396-3225
Sarah M HeisslerDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-6972-7940
Isabelle DeschênesDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-1812-7267
Krishna ChinthalapudiDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-3669-561X

Funding

Sodium Channels and Cardiac ArrhythmiasR01HL094450 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2010 to 2022
$4.0M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL094450NHLBI NIH HHS R01 HL094450
6 · The paper itself

Abstract

Voltage-gated Na

Indexed as

Ion Channel GatingNAV1.5 Voltage-Gated Sodium ChannelAction PotentialsCryoelectron MicroscopyHumansMolecular Dynamics SimulationProtein ConformationProtein DomainsSodiumNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanSodiumaction potentialsarrhythmiascryo-EMelectrophysiological studiessodium channels

Identifiers

PMID40366698
PMCPMC12107192

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.