Evidence map›Paper›PMID 40366697›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging.

Qiuyi Wang, Yue Wang, Yujie Lin, Jiawen Zhou, Zhiyuan Mao, Xin Gu, Haiyun Chen, Jiyu Li, Ao Chen, Jin'ge Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Qiuyi Wang *Department of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yue Wang *Department of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yujie Lin *Department of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Jiawen Zhou *Department of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Zhiyuan Mao *Department of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Xin GuDepartment of Cardiology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214062, China.
Haiyun ChenDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.ORCID 0000-0002-8626-1695
Jiyu LiDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Ao ChenDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Jin'ge ZhangDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Rong WangDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Yingming ZhaoDepartment of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, China.
Mufeng GuDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Qing LiDepartment of Science and Technology, Jiangsu Health Vocational College, Nanjing, Jiangsu 210029, China.
Yongjie ZhangDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Jianliang JinDepartment of Human Anatomy, School of Basic Medical Sciences, Key Laboratory for Aging and Disease, Nanjing Medical University, Nanjing, Jiangsu 211166, China.ORCID 0000-0003-3312-3210

Funding

Jiangsu Province Ordinary University Innovative Research Project KYCX23_1916JST | Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation) BK20151554MOST | National Natural Science Foundation of China (NSFC) 82271614 81871097 81571371Qinglan Project of Jiangsu Province of China (Qing Lan Project) 2024-14 and 2020-10 to J.J.
6 · The paper itself

Abstract

New immunosenescence targets for preventing senescence-associated pathological cardiac hypertrophy (SA-PCH) need to be explored. In the present study, with physiologically aged human and mouse samples, the IL-17A level increased with physiological aging, heart failure (HF), and SA-PCH and was negatively correlated with thymic Bmi-1 expression.

Indexed as

AgingInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Polycomb Repressive Complex 1Th17 CellsThymus GlandAnimalsCell DifferentiationCellular SenescenceFemaleHeart FailureHumansMaleMiceMice, Inbred C57BLProto-Oncogene ProteinsBMI1 protein, humanBmi1 protein, mouseIL17A protein, humanIl17a protein, mouseInterleukin-17Nuclear Receptor Subfamily 1, Group F, Member 3Polycomb Repressive Complex 1Proto-Oncogene ProteinsReceptors, Antigen, T-Cell, gamma-deltaBmi-1IL-17ARORγtsenescence-associated pathological cardiac hypertrophyγδT17 cells

Identifiers

PMID40366697
PMCPMC12107095

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.