Evidence map›Paper›PMID 40366685›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Electric field-induced pore constriction in the human K

Venkata Shiva Mandala, Roderick MacKinnon

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Spatial Deconstruction of the Plasma Membrane.Journal of the American Chemical Society · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Molecular contacts in self-assembling clusters of membrane proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Venkata Shiva MandalaLaboratory of Molecular Neurobiology and Biophysics, HHMI, The Rockefeller University, New York, NY 10065.
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics, HHMI, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-7605-4679

Funding

HHMI (HHMI) HHMIJane Coffin Childs Memorial Fund for Medical Research (JCC) 61-1781
6 · The paper itself

Abstract

Gating in voltage-dependent ion channels is regulated by the transmembrane voltage. This form of regulation is enabled by voltage-sensing domains (VSDs) that respond to transmembrane voltage differences by changing their conformation and exerting force on the pore to open or close it. Here, we use cryogenic electron microscopy to study the neuronal K

Indexed as

Ion Channel GatingShab Potassium ChannelsCryoelectron MicroscopyElectricityHumansMembrane PotentialsModels, MolecularProtein ConformationProtein DomainsKCNB1 protein, humanShab Potassium Channelscryo-EMKv2.1 channelmembrane potentialpotassium channelvoltage gating

Identifiers

PMID40366685
PMCPMC12107148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.