ReviewMolecular diversity2026
2-Amino-1,4-naphthoquinone as a key precursor for naphthoquinone-fused N-heterocycles: synthetic approaches and mechanistic perspectives.
Review in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
2-Amino-1,4-naphthoquinone has gained significant attention as a key precursor for constructing naphthoquinone-fused N-heterocycles, a class of compounds with broad applications in medicinal chemistry, materials science, and organic synthesis. Its unique structure, characterized by a reactive C-3 position and an amino group, facilitates a wide range of reactions and synthetic strategies. This review provides a comprehensive overview of recent advancements (2012-2024) in utilizing 2-amino-1,4-naphthoquinone for the development of N-heterocyclic frameworks integrating synthetic approaches with mechanistic insights. It is organized based on the type of heterocyclic rings formed, leveraging the C,N-binucleophilic properties of 2-amino-1,4-naphthoquinone.
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