Evidence map›Paper›PMID 40366524›Full record

ArticleInflammation2025

Intranasal Immunotherapy with Allergen-Loaded Extracellular Vesicles from Mast Cells Alleviates Allergic Asthma Inflammation in a Murine Model.

Liao Huanjin, Peng Xia, Yin Yue, Ge Yiqing, Li Yanning, Wang Juan, Li Jia, Lin Lihui, Li Li, Xie Guogang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mast cell-derived extracellular vesicles in lung diseases: roles in pulmonary inflammation, immune regulation, and microenvironmental remodeling.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liao HuanjinDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Peng XiaDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Yin YueDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Ge YiqingDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Li YanningDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Wang JuanDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Li JiaDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Lin LihuiDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Li LiDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. annylish@126.com.
Xie GuogangDepartment of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. freeman811@163.com.

Funding

National Natural Science Foundation of China 81871267National Natural Science Foundation of China 82370033Science and Technology Commission of Shanghai Municipality "Shanghai Sailing Program" 22YF1435600the China National Center for Biotechnology Development 2022YFC2009604the Shanghai Shenkang Hospital Development Center SHDC2020CR3007A
6 · The paper itself

Abstract

Allergen immunotherapy (AIT) is the only treatment that can alter the course of allergic diseases by inducing immune tolerance through long-term, repeated low-dose allergen exposure. Nonetheless, AIT persistently faces challenges necessitating resolution, particularly in relation to treatment duration, the incidence of adverse reactions, and patient adherence. Extracellular vesicles (EVs) are promising drug delivery carriers for medications, vaccines, and targeted antibodies. Previously, we demonstrated that intravenous bone marrow-derived mast cell EVs (BMMC-EVs) can reduce allergic airway inflammation in asthmatic mice by interacting with free IgE. This study explores the potential of intranasally administered BMMC-EVs loaded with dermatophagoides farinae extracts to induce local immune tolerance and more effectively alleviate allergic asthma in mice. BMMC were co-cultured with the crude extract of dermatophagoides farina (DfE). BMMC-EVs-DfE were obtained and analyzed for the presence and concentration of DfE. The allergic asthma model was sensitized by intraperitoneal injection of DfE and Al(OH)

Indexed as

AllergensAsthmaDesensitization, ImmunologicExtracellular VesiclesMast CellsAdministration, IntranasalAnimalsAntigens, DermatophagoidesBronchoalveolar Lavage FluidDisease Models, AnimalFemaleInflammationMiceMice, Inbred BALB CAllergensAntigens, DermatophagoidesAllergen immunotherapyAsthmaExtracellular vesiclesInflammationMast cell

Identifiers

PMID40366524
PMCPMC12722274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.