ArticleDiscover oncology2025
Enhancement of radiation effects by Plantago major in MCF-7 human breast cancer: an animal study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Total Phenolic, Flavonoid Content, and Antioxidant Activity of Selected Wild Edible Plants from Yemen.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Review
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10 authors.
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Abstract
purposeWe aimed to evaluate the potential effects of Plantago major (PM) to enhance the radiosensitivity of human breast adenocarcinoma cell line (MCF-7) in an animal model. MATERIALS AND
methodsSeventy-two female Balb/c mice were divided into nine groups (8 mice per group) as follows: MCF-7 breast cancer control group, MCF-7+low dose of PM (1000 mg/kg), MCF-7+high dose of PM (1500 mg/kg), MCF-7+3 Gy superficial X-ray, MCF-7+5 Gy superficial X-ray, MCF-7+1000&1500 mg/kg of PM with 3 and 5 Gy irradiations. For each treatment group, micronuclei in 500 binucleate MCF-7 cells from a minimum of three experiments were counted. The alkaline comet assay was used to calculate % DNA in the tail and % of apoptotic comets. The tumor size in the treated groups (3 mice per group) was assessed at 4- and 8-weeks post-treatment.
resultsThe number of total micronuclei and binucleated micronuclei in the PM and/or irradiation treated groups was significantly higher than in the control group (P < 0.05). Irradiation+PM resulted in a significant increase treatment effect compared to the irradiation-only groups (P < 0.01). In addition, the higher PM concentration had a significantly higher number of micronucleated binucleate cells when combined with 5 Gy irradiation (P = 0.022). Irradiation alone or in combination with PM resulted in significant increases in percentages of DNA in tail and apoptotic comet values compared to the PM-only treatment groups (P < 0.02). Combining 5 Gy of irradiation with 1000 mg/kg of PM led to a 26% reduction in tumor size (0.28±0.04 vs. 0.38 ± 0.03) after 4 weeks, and combining 5 Gy of irradiation with 1500 mg/kg of PM resulted in a 40% decrease in tumor volume after 4 weeks (0.21±0.04 vs. 0.35±0.03).
conclusionPM extract at both doses demonstrated an antitumor effect on induced MCF-7 breast cancer tumors, with this effect being enhanced when combined with irradiation.
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